Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Electrophysiological Correlates of Sensorimotor System Neurotoxicology

Electrophysiological Correlates of Sensorimotor System Neurotoxicology In this review we consider the electrophysiological consequences of neuro­ pathological changes induced by toxic chemicals in sensorimotor systems. A large body of neurotoxicological data is not covered, including that derived from observations of the acute effects of toxic chemicals on neural systems. The toxicological and/or pharmacological effects of such chemical-neural in­ teractions in many cases leave no residual pathology; such data are adequately reviewed elsewhere. In most instances, too few studies using neurotoxic chemicals have been reported to permit structural-functional correlations. Hence, we have relied on analogous studies from other areas of neurological research, particularly ax­ otomy, on the assumption that while the neuron may be injured in various ways, it can respond to diverse forms of injury in only a few stereotyped fashions. Systemic exposure to toxic chemicals exposes all levels of the neuron: the perikaryon, the axon, the nerve endings, and the target organs. Possible multiple sites of chemical attack tend to confound cause-effect relationships in a system as dynamic as a neuron and its target(s) of innervation. Particular manifestations of neurotoxicity thus may depend on one or more of the follow517 0362-1642/86/0415-0517$02.00 BAKER & LOWNDES (1), toxicokinetics of the compound (cf 5), and species http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Pharmacology and Toxicology Annual Reviews

Electrophysiological Correlates of Sensorimotor System Neurotoxicology

Download PDF
29 pages

Loading next page...
 
/lp/annual-reviews/electrophysiological-correlates-of-sensorimotor-system-neurotoxicology-IKqx03VoWU

References

References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.

Publisher
Annual Reviews
Copyright
Copyright 1986 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0362-1642
eISSN
1545-4304
DOI
10.1146/annurev.pa.26.040186.002505
pmid
3521462
Publisher site
See Article on Publisher Site

Abstract

In this review we consider the electrophysiological consequences of neuro­ pathological changes induced by toxic chemicals in sensorimotor systems. A large body of neurotoxicological data is not covered, including that derived from observations of the acute effects of toxic chemicals on neural systems. The toxicological and/or pharmacological effects of such chemical-neural in­ teractions in many cases leave no residual pathology; such data are adequately reviewed elsewhere. In most instances, too few studies using neurotoxic chemicals have been reported to permit structural-functional correlations. Hence, we have relied on analogous studies from other areas of neurological research, particularly ax­ otomy, on the assumption that while the neuron may be injured in various ways, it can respond to diverse forms of injury in only a few stereotyped fashions. Systemic exposure to toxic chemicals exposes all levels of the neuron: the perikaryon, the axon, the nerve endings, and the target organs. Possible multiple sites of chemical attack tend to confound cause-effect relationships in a system as dynamic as a neuron and its target(s) of innervation. Particular manifestations of neurotoxicity thus may depend on one or more of the follow517 0362-1642/86/0415-0517$02.00 BAKER & LOWNDES (1), toxicokinetics of the compound (cf 5), and species

Journal

Annual Review of Pharmacology and Toxicology – Annual Reviews

Published: Apr 1, 1986

There are no references for this article.