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Factors Affecting Resistance to Infection

Factors Affecting Resistance to Infection FACTORS AFFECTING RESISTANCE TO INFECTIOW·2 By SANFORD S. ELBERG Department o Bacteriology, University o Cali f f fornia, Berkeley, Cali fornia Patterns of investigation on the subject of nonspecific resistance in the year under review have been greatly clarified by papers on organizational aspects as well as by specific contributions of a research nature. Miles, in two stimulating essays (1, 2) has analyzed the subject of bacterial invasion in terms of the constitutive and adaptive mechanisms with which the host is endowed. This method of analysis allows many hitherto unrelated yet none­ theless important observations to be considered as determinants or mediators of infection or resistance. The idea of determinants has been plausibly dis­ cussed by Dubos who suggests that the interplay between host and parasite within the microenvironment of inflammation should be the object of more study for a better understanding of the mechanisms by which latent infec­ tions are activated. The phagocytic theory and the survival value of the adaptive responses of cellular and humoral components of inflammation are re-examined by both Miles (1) and Dubos (3, 4, 5) not as to the oft-discussed significance of Metschnikow's observations on Daphnia but in terms of the chemical http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Microbiology Annual Reviews

Factors Affecting Resistance to Infection

Elberg, S S
Annual Review of Microbiology , Volume 10 (1) – Oct 1, 1956
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Publisher
Annual Reviews
Copyright
Copyright 1956 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0066-4227
eISSN
1545-3251
DOI
10.1146/annurev.mi.10.100156.000245
pmid
13363353
Publisher site
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Abstract

FACTORS AFFECTING RESISTANCE TO INFECTIOW·2 By SANFORD S. ELBERG Department o Bacteriology, University o Cali f f fornia, Berkeley, Cali fornia Patterns of investigation on the subject of nonspecific resistance in the year under review have been greatly clarified by papers on organizational aspects as well as by specific contributions of a research nature. Miles, in two stimulating essays (1, 2) has analyzed the subject of bacterial invasion in terms of the constitutive and adaptive mechanisms with which the host is endowed. This method of analysis allows many hitherto unrelated yet none­ theless important observations to be considered as determinants or mediators of infection or resistance. The idea of determinants has been plausibly dis­ cussed by Dubos who suggests that the interplay between host and parasite within the microenvironment of inflammation should be the object of more study for a better understanding of the mechanisms by which latent infec­ tions are activated. The phagocytic theory and the survival value of the adaptive responses of cellular and humoral components of inflammation are re-examined by both Miles (1) and Dubos (3, 4, 5) not as to the oft-discussed significance of Metschnikow's observations on Daphnia but in terms of the chemical

Journal

Annual Review of Microbiology – Annual Reviews

Published: Oct 1, 1956

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