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Function and Regulation of Aminoacyl-tRNA Synthetases in Prokaryotic and Eukaryotic Cells

Function and Regulation of Aminoacyl-tRNA Synthetases in Prokaryotic and Eukaryotic Cells Aminoacyl-tRNA synthetases are essential elements in cellu lar protein synthesis because they are responsible for the attachment of each of the 20 protein amino acids to appropriate tRNA molecules. Since their discovery 1 8 years ago. considerable information has been learned about these enzymes. and during the past five years work has accelerated on many aspects of their structure, function, origin, and regulation. A review of even this recent progress is impossible in anything less than a full monograph. but fortunately two reviews have appeared within the past several months which neatly complement the specialized coverage we have chosen here. Soli & Schimmel (268) and Kisselev & Favorova (I SO) deal brilliantly with the molecular and catalytic properties of aminoacyl-tRNA synthetases. We touch upon these subjects. but not comprehensively. Our task has been to review critically the work on the biological regulation of these essential enzymes. We have. therefore. summa­ rized the knowledge about the structure, enzymology. genetics, and function of synthetases only to provide a foundation for our discussion of how these enzymes are regulated. We are fortunate also in being able to refer readers to the two related articles in this volume. one on regulation of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Microbiology Annual Reviews

Function and Regulation of Aminoacyl-tRNA Synthetases in Prokaryotic and Eukaryotic Cells

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Publisher
Annual Reviews
Copyright
Copyright 1975 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0066-4227
eISSN
1545-3251
DOI
10.1146/annurev.mi.29.100175.001243
pmid
1180514
Publisher site
See Article on Publisher Site

Abstract

Aminoacyl-tRNA synthetases are essential elements in cellu lar protein synthesis because they are responsible for the attachment of each of the 20 protein amino acids to appropriate tRNA molecules. Since their discovery 1 8 years ago. considerable information has been learned about these enzymes. and during the past five years work has accelerated on many aspects of their structure, function, origin, and regulation. A review of even this recent progress is impossible in anything less than a full monograph. but fortunately two reviews have appeared within the past several months which neatly complement the specialized coverage we have chosen here. Soli & Schimmel (268) and Kisselev & Favorova (I SO) deal brilliantly with the molecular and catalytic properties of aminoacyl-tRNA synthetases. We touch upon these subjects. but not comprehensively. Our task has been to review critically the work on the biological regulation of these essential enzymes. We have. therefore. summa­ rized the knowledge about the structure, enzymology. genetics, and function of synthetases only to provide a foundation for our discussion of how these enzymes are regulated. We are fortunate also in being able to refer readers to the two related articles in this volume. one on regulation of

Journal

Annual Review of MicrobiologyAnnual Reviews

Published: Oct 1, 1975

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