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Gamma/Delta Cells

Gamma/Delta Cells Before TCR rearrangements, T cell progenitors are committed not only to the ap and yJ T cell lineage but also to various subsets of both lineages. In the mouse, distinct yJ T cell subsets can develop in the fetal thymus, the adult thymus, or independently of a thymus, probably in intestinal epithelia. The two subsets that develop in the fetal thymus home to and are maintained throughout adult life in the skin and the mucosa of the uterus, vagina, and tongue. They are monospecific. This unusual restriction in receptor repertoires is the result of severe limitations in the generation of diversity in the fetal progenitors of these subsets and the thymic selec­ tion. After birth, one yJ T cell subset appears in the blood, spleen, and lymph nodes and one in the intestinal epithelia. The receptor repertoires of these subsets are characterized by the preferential usage of particular Vy gene segments and extensive junctional diversity. Several murine and human yJ T cell clones have been shown to recognize classical MHC class I and class II proteins or MHC class I-like proteins, and in very few cases the presented peptides are known. We suspect that the various murine yJ http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Immunology Annual Reviews

Gamma/Delta Cells

Haas, W; Pereira, P; Tonegawa, S
Annual Review of Immunology , Volume 11 (1) – Apr 1, 1993
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Publisher
Annual Reviews
Copyright
Copyright 1993 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0732-0582
eISSN
1545-3278
DOI
10.1146/annurev.iy.11.040193.003225
pmid
8476575
Publisher site
See Article on Publisher Site

Abstract

Before TCR rearrangements, T cell progenitors are committed not only to the ap and yJ T cell lineage but also to various subsets of both lineages. In the mouse, distinct yJ T cell subsets can develop in the fetal thymus, the adult thymus, or independently of a thymus, probably in intestinal epithelia. The two subsets that develop in the fetal thymus home to and are maintained throughout adult life in the skin and the mucosa of the uterus, vagina, and tongue. They are monospecific. This unusual restriction in receptor repertoires is the result of severe limitations in the generation of diversity in the fetal progenitors of these subsets and the thymic selec­ tion. After birth, one yJ T cell subset appears in the blood, spleen, and lymph nodes and one in the intestinal epithelia. The receptor repertoires of these subsets are characterized by the preferential usage of particular Vy gene segments and extensive junctional diversity. Several murine and human yJ T cell clones have been shown to recognize classical MHC class I and class II proteins or MHC class I-like proteins, and in very few cases the presented peptides are known. We suspect that the various murine yJ

Journal

Annual Review of Immunology – Annual Reviews

Published: Apr 1, 1993

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