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Heterogeneity of Natural Killer Cells

Heterogeneity of Natural Killer Cells Natural killer cells were discovered about ten years ago (1-5) during studies of cell-mediated cytotoxicity. Although investigators expected to find specific cytotoxic activity of tumor-bearing individuals against autologous tumor cells or against allogeneic tumors of similar or the same histologic type, appreciable cytotoxic activity was observed with lymphocytes from normal individuals. Since this time, the studies of natural killer cells have expanded into a broad and multifaceted research area, stimulated by the increasing indications that these cells may play important roles in natural host resistance against cancer and infectious diseases (6-24). With the wide array of recent studies related to natural cell-mediated cytotoxicity, there has been considerable diversity in the terminology related to the effector cells and consequently some confusion in the literature. However, at a recent workshop devoted to the study of natural killer cells, a consensus definition for these effector cells was developed (25). Natural killer (NK) cells were defined as effector cells with spontaneous cyto­ toxicity against various target cells; these effector �ells lack the properties of classical macrophages, granulocytes, or cytotoxic T lymphocytes (CTL); and the observed cytotoxicity does not show restriction related to the major his­ tocompatibility complex (MHC). This definition is sufficiently http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Immunology Annual Reviews

Heterogeneity of Natural Killer Cells

Ortaldo, J R; Herberman, R B
Annual Review of Immunology , Volume 2 (1) – Apr 1, 1984
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References (58)

Publisher
Annual Reviews
Copyright
Copyright 1984 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0732-0582
eISSN
1545-3278
DOI
10.1146/annurev.iy.02.040184.002043
pmid
6399848
Publisher site
See Article on Publisher Site

Abstract

Natural killer cells were discovered about ten years ago (1-5) during studies of cell-mediated cytotoxicity. Although investigators expected to find specific cytotoxic activity of tumor-bearing individuals against autologous tumor cells or against allogeneic tumors of similar or the same histologic type, appreciable cytotoxic activity was observed with lymphocytes from normal individuals. Since this time, the studies of natural killer cells have expanded into a broad and multifaceted research area, stimulated by the increasing indications that these cells may play important roles in natural host resistance against cancer and infectious diseases (6-24). With the wide array of recent studies related to natural cell-mediated cytotoxicity, there has been considerable diversity in the terminology related to the effector cells and consequently some confusion in the literature. However, at a recent workshop devoted to the study of natural killer cells, a consensus definition for these effector cells was developed (25). Natural killer (NK) cells were defined as effector cells with spontaneous cyto­ toxicity against various target cells; these effector �ells lack the properties of classical macrophages, granulocytes, or cytotoxic T lymphocytes (CTL); and the observed cytotoxicity does not show restriction related to the major his­ tocompatibility complex (MHC). This definition is sufficiently

Journal

Annual Review of Immunology – Annual Reviews

Published: Apr 1, 1984

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