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Immunity to Intracellular Bacteria

Immunity to Intracellular Bacteria Intracellular bacteria are endowed with the capacity to survive and rep­ licate inside mononuclear phagocytes (MP) and, sometimes, within certain other host cells. MP are potent effector cells that are able to engulf and kill many bacterial invaders. Therefore, intracellular bacteria had to exploit potent evasion mechanisms that allow their survival in this hostile environ­ ment. At the early phase, natural killer cells activate antibacterial defense mechanisms. During intracellular persistence, microbial proteins are pro­ cessed and presented, thus initiating T cell activation. By secreting inter­ leukins, CD4 a/ p TH I cells activate MP, converting them from a habitat to a potent effector cell; TH2-dependent activities seem to be of minor importance. Cytolytic CD8 T cells represent a further element of protec­ tion. In the case of Listeria monocytogenes, the gene products responsible for virulence and for the introduction of antigens into the MHC class I pathway are being characterized. Increasing evidence points to a role of y/b T lymphocytes in antibacterial immunity, although their precise function remains to be elucidated. Protection in the host is a local event focussed on granulomatous lesions. MP accumulate at the site of microbial growth and become activated through the CD4 T http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Immunology Annual Reviews

Immunity to Intracellular Bacteria

Kaufmann, S H E
Annual Review of Immunology , Volume 11 (1) – Apr 1, 1993
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Publisher
Annual Reviews
Copyright
Copyright 1993 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0732-0582
eISSN
1545-3278
DOI
10.1146/annurev.iy.11.040193.001021
pmid
8476559
Publisher site
See Article on Publisher Site

Abstract

Intracellular bacteria are endowed with the capacity to survive and rep­ licate inside mononuclear phagocytes (MP) and, sometimes, within certain other host cells. MP are potent effector cells that are able to engulf and kill many bacterial invaders. Therefore, intracellular bacteria had to exploit potent evasion mechanisms that allow their survival in this hostile environ­ ment. At the early phase, natural killer cells activate antibacterial defense mechanisms. During intracellular persistence, microbial proteins are pro­ cessed and presented, thus initiating T cell activation. By secreting inter­ leukins, CD4 a/ p TH I cells activate MP, converting them from a habitat to a potent effector cell; TH2-dependent activities seem to be of minor importance. Cytolytic CD8 T cells represent a further element of protec­ tion. In the case of Listeria monocytogenes, the gene products responsible for virulence and for the introduction of antigens into the MHC class I pathway are being characterized. Increasing evidence points to a role of y/b T lymphocytes in antibacterial immunity, although their precise function remains to be elucidated. Protection in the host is a local event focussed on granulomatous lesions. MP accumulate at the site of microbial growth and become activated through the CD4 T

Journal

Annual Review of Immunology – Annual Reviews

Published: Apr 1, 1993

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