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Immunobiology of Eosinophils

Immunobiology of Eosinophils The eosinophilic leukocyte was discovered by Paul Ehrlich in 1879 when he stained fixed blood smears with aniline dyes (1). By the early part of this century a voluminous literature on eosinophils had accumulated and the asso­ ciation of blood eosinophilia with helminth infection and bronchial asthma was established . Later, tissue eosinophilia was shown following cutaneous allergic reactions (2). However, only in the past decade has the striking ability of the eosinophil to kill helminths been shown. This observation has raised the possibilitY, that the same toxic properties of the eosinophil, beneficial when focused on a helminth invader, might be turned against the host during hyper­ sensitivity diseases. Finally, new information regarding eosinophil granule proteins has been obtained and the role of these proteins in eosinophil function has been investigated. In this review we summarize present knowledge of the eosinophil with emphasis on its granule proteins and on its likely role in helminth infection and hypersensitivity diseases. EOSINOPHIL-ASSOCIATED PROTEINS The granules of the eosinophil are distinctive , first in that they stain avidly with acid dyes and second in their characteristic appearance in the electron microscope . Three types of eosinophil granules are recognized. Primary gran­ ules http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Immunology Annual Reviews

Immunobiology of Eosinophils

Gleich, G J; Loegering, D A
Annual Review of Immunology , Volume 2 (1) – Apr 1, 1984
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References (53)

Publisher
Annual Reviews
Copyright
Copyright 1984 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0732-0582
eISSN
1545-3278
DOI
10.1146/annurev.iy.02.040184.002241
pmid
6399849
Publisher site
See Article on Publisher Site

Abstract

The eosinophilic leukocyte was discovered by Paul Ehrlich in 1879 when he stained fixed blood smears with aniline dyes (1). By the early part of this century a voluminous literature on eosinophils had accumulated and the asso­ ciation of blood eosinophilia with helminth infection and bronchial asthma was established . Later, tissue eosinophilia was shown following cutaneous allergic reactions (2). However, only in the past decade has the striking ability of the eosinophil to kill helminths been shown. This observation has raised the possibilitY, that the same toxic properties of the eosinophil, beneficial when focused on a helminth invader, might be turned against the host during hyper­ sensitivity diseases. Finally, new information regarding eosinophil granule proteins has been obtained and the role of these proteins in eosinophil function has been investigated. In this review we summarize present knowledge of the eosinophil with emphasis on its granule proteins and on its likely role in helminth infection and hypersensitivity diseases. EOSINOPHIL-ASSOCIATED PROTEINS The granules of the eosinophil are distinctive , first in that they stain avidly with acid dyes and second in their characteristic appearance in the electron microscope . Three types of eosinophil granules are recognized. Primary gran­ ules

Journal

Annual Review of Immunology – Annual Reviews

Published: Apr 1, 1984

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