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Interleukin-10

Interleukin-10 Activated hemopoietic cells secrete numerous proteins. Several of these proteins, the cytokines, play important roles in the regulation of immune responses by controlling proliferation, differentiation, and the effector functions of immune cells. Most cytokines have more than one biological activity; which activity is the most important probably depends on the local context in which the cytokine is produced. Discovery of the cytokine 165 0732-0582/93/0410-'0165$02.00 MOORE ET AL interieukin-IO (IL-lO) was based on three different in vitro biological activities. The cytokine synthesis inhibitory factor (CSIF) activity of IL-IO was discovered by searching for a product of T helper 2 (Th2) cells that would inhibit proliferation, effector function, and possibly development of T helper I (Th 1) cells ( l , 2), in a way analogous to inhibition of Th2 pro­ liferation by IFNy, a Thl cytokine (3, 4). CSIF activity was produced by Th2 clones and inhibited production of cytokines such as interferon-/, (IFNI') by Thl clones ( 1). Based on this biological activity, cDNA clones encoding mouse IL-IO (mIL-IO) were isolated (5). Subsequently, cDNA clones encoding human IL-IO (hIL- lO) were identified by cross-hybrid­ ization with the mouse cDNA (6). Mouse B cell lymphomas expressed an activity that http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Immunology Annual Reviews

Interleukin-10

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Publisher
Annual Reviews
Copyright
Copyright 1993 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0732-0582
eISSN
1545-3278
DOI
10.1146/annurev.iy.11.040193.001121
pmid
8386517
Publisher site
See Article on Publisher Site

Abstract

Activated hemopoietic cells secrete numerous proteins. Several of these proteins, the cytokines, play important roles in the regulation of immune responses by controlling proliferation, differentiation, and the effector functions of immune cells. Most cytokines have more than one biological activity; which activity is the most important probably depends on the local context in which the cytokine is produced. Discovery of the cytokine 165 0732-0582/93/0410-'0165$02.00 MOORE ET AL interieukin-IO (IL-lO) was based on three different in vitro biological activities. The cytokine synthesis inhibitory factor (CSIF) activity of IL-IO was discovered by searching for a product of T helper 2 (Th2) cells that would inhibit proliferation, effector function, and possibly development of T helper I (Th 1) cells ( l , 2), in a way analogous to inhibition of Th2 pro­ liferation by IFNy, a Thl cytokine (3, 4). CSIF activity was produced by Th2 clones and inhibited production of cytokines such as interferon-/, (IFNI') by Thl clones ( 1). Based on this biological activity, cDNA clones encoding mouse IL-IO (mIL-IO) were isolated (5). Subsequently, cDNA clones encoding human IL-IO (hIL- lO) were identified by cross-hybrid­ ization with the mouse cDNA (6). Mouse B cell lymphomas expressed an activity that

Journal

Annual Review of Immunology – Annual Reviews

Published: Apr 1, 1993

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