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Interleukin 2

Interleukin 2 Compared to the last twenty years of lymphokine research, the past two years of effort directed towards understanding the T-lymphocytotrophic hormone, interleukin 2 OL-2) (1-3), have resulted in an exponential increase in our gra.�p of the importance of intercellular communicating molecules. As in many other fields of biology, breakthroughs have resulted from the application of monoclonal antibodies and molecular biology to this area of research. In addi­ tion. an endocrinologic approach has provided fresh insight into the mecha­ nism whereby IL·2 promotes T-cell proliferation. Consequently, the tools are at last available for new experimental approaches to fundamental questions in im!llUnology and cell biology. The idea that lymphocytes are stimulated to undergo DNA duplication and mitosis by antigen triggering of specific receptors has slowly evolved to the understanding that while this concept is correct, the process is carried forward by discernible molecular mechanisms. Through painstaking cellular and bio­ chemical experiments a consensus has finally been reached that IL-2 is a critical biologic activity, released from antigen-triggered lymphocytes within hours of activation, that functions to mediate a switch in T cells from 01 into the proliferative phases (i.e. S, O2, and M) of the cell cycle. However, until re cent http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Immunology Annual Reviews

Interleukin 2

Smith, K A
Annual Review of Immunology , Volume 2 (1) – Apr 1, 1984
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Publisher
Annual Reviews
Copyright
Copyright 1984 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0732-0582
eISSN
1545-3278
DOI
10.1146/annurev.iy.02.040184.001535
pmid
6443342
Publisher site
See Article on Publisher Site

Abstract

Compared to the last twenty years of lymphokine research, the past two years of effort directed towards understanding the T-lymphocytotrophic hormone, interleukin 2 OL-2) (1-3), have resulted in an exponential increase in our gra.�p of the importance of intercellular communicating molecules. As in many other fields of biology, breakthroughs have resulted from the application of monoclonal antibodies and molecular biology to this area of research. In addi­ tion. an endocrinologic approach has provided fresh insight into the mecha­ nism whereby IL·2 promotes T-cell proliferation. Consequently, the tools are at last available for new experimental approaches to fundamental questions in im!llUnology and cell biology. The idea that lymphocytes are stimulated to undergo DNA duplication and mitosis by antigen triggering of specific receptors has slowly evolved to the understanding that while this concept is correct, the process is carried forward by discernible molecular mechanisms. Through painstaking cellular and bio­ chemical experiments a consensus has finally been reached that IL-2 is a critical biologic activity, released from antigen-triggered lymphocytes within hours of activation, that functions to mediate a switch in T cells from 01 into the proliferative phases (i.e. S, O2, and M) of the cell cycle. However, until re cent

Journal

Annual Review of Immunology – Annual Reviews

Published: Apr 1, 1984

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