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Iron Absorption and Transport in Microorganisms

Iron Absorption and Transport in Microorganisms AND SCOPE The study of iron assimilation systems in microorganisms, particularly in enteric bacteria, has become an active field of research in recent years. There are several reasons for this state of affairs. One pathway of iron uptake involves special carriers, termed siderophores (1), and the matching mem­ brane receptors. Since the latter are used by specific phages and bacteriocins as attachment sites (2), the mode of infection by these noxious agents can be studied via examination of the iron-uptake apparatus. The transport system is regulated by the iron nutritional status of the cell and several of the membrane proteins involved can be visualized in polyacrylamide gels. Thus, iron assimilation in procaryotic species such as Escherichia coli affords an ideal opportunity for application of the powerful techniques of modem molecular biology and extends beyond iron transport per se to more general transmembrane permeation processes and their regulation. 0199/9885/8110715-0027$01.00 NEILANDS Microbial iron assimilation has become popular in another context. It is linked rather directly to several practical applications. Because little free iron exists in the tissues of animals and plants, the capacity of invading pathogens to acquire enough of this "precious metal" to satisfy demands of growth may constitute http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Nutrition Annual Reviews

Iron Absorption and Transport in Microorganisms

Annual Review of Nutrition , Volume 1 (1) – Jul 1, 1981

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Publisher
Annual Reviews
Copyright
Copyright 1981 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0199-9885
eISSN
1545-4312
DOI
10.1146/annurev.nu.01.070181.000331
pmid
6226306
Publisher site
See Article on Publisher Site

Abstract

AND SCOPE The study of iron assimilation systems in microorganisms, particularly in enteric bacteria, has become an active field of research in recent years. There are several reasons for this state of affairs. One pathway of iron uptake involves special carriers, termed siderophores (1), and the matching mem­ brane receptors. Since the latter are used by specific phages and bacteriocins as attachment sites (2), the mode of infection by these noxious agents can be studied via examination of the iron-uptake apparatus. The transport system is regulated by the iron nutritional status of the cell and several of the membrane proteins involved can be visualized in polyacrylamide gels. Thus, iron assimilation in procaryotic species such as Escherichia coli affords an ideal opportunity for application of the powerful techniques of modem molecular biology and extends beyond iron transport per se to more general transmembrane permeation processes and their regulation. 0199/9885/8110715-0027$01.00 NEILANDS Microbial iron assimilation has become popular in another context. It is linked rather directly to several practical applications. Because little free iron exists in the tissues of animals and plants, the capacity of invading pathogens to acquire enough of this "precious metal" to satisfy demands of growth may constitute

Journal

Annual Review of NutritionAnnual Reviews

Published: Jul 1, 1981

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