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Low-Molecular-Weight Enzyme Inhibitors of Microbial Origin

Low-Molecular-Weight Enzyme Inhibitors of Microbial Origin A main objective of research on antibiotics is to find new active agents. In this research, it is most important to explore new research areas where new microbial products with potential usefulness can be found. By 1965, exten­ sive advancement took place in the chemistry of natural products and made possible the elucidation of the structure of low-molecular-weight com­ pounds in a short period of time. Moreover, the research in enzymology of biological functions and disease processes began to show rapid progress. It seems logical, therefore, that research on antibiotics be extended to enzyme inhibitors that have various pharmacological activities. Thus, the study of low-molecular-weight enzyme inhibitors was initiated by Umezawa (95). Since the discovery of a protease inhibitor was reported in 1969, nearly 50 inhibitors of various enzymes have been found in microbial culture filtrates. Their structures were elucidated, most of them were chemically synthe­ sized, and new types of structures for inhibition were disclosed. These are reviewed by Umezawa (95-97, 99) and Aoyagi (2, 12). It is often said that the reason microorganisms in nature produce antibi­ otics is to suppress the growth of the competitors. However, most enzyme inhibitors produced by microorganisms have no significant http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Microbiology Annual Reviews

Low-Molecular-Weight Enzyme Inhibitors of Microbial Origin

Umezawa, Hamao
Annual Review of Microbiology , Volume 36 (1) – Oct 1, 1982
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Publisher
Annual Reviews
Copyright
Copyright 1982 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0066-4227
eISSN
1545-3251
DOI
10.1146/annurev.mi.36.100182.000451
pmid
6293372
Publisher site
See Article on Publisher Site

Abstract

A main objective of research on antibiotics is to find new active agents. In this research, it is most important to explore new research areas where new microbial products with potential usefulness can be found. By 1965, exten­ sive advancement took place in the chemistry of natural products and made possible the elucidation of the structure of low-molecular-weight com­ pounds in a short period of time. Moreover, the research in enzymology of biological functions and disease processes began to show rapid progress. It seems logical, therefore, that research on antibiotics be extended to enzyme inhibitors that have various pharmacological activities. Thus, the study of low-molecular-weight enzyme inhibitors was initiated by Umezawa (95). Since the discovery of a protease inhibitor was reported in 1969, nearly 50 inhibitors of various enzymes have been found in microbial culture filtrates. Their structures were elucidated, most of them were chemically synthe­ sized, and new types of structures for inhibition were disclosed. These are reviewed by Umezawa (95-97, 99) and Aoyagi (2, 12). It is often said that the reason microorganisms in nature produce antibi­ otics is to suppress the growth of the competitors. However, most enzyme inhibitors produced by microorganisms have no significant

Journal

Annual Review of Microbiology – Annual Reviews

Published: Oct 1, 1982

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