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Murine Major Histocompatibility Complex Class-I Mutants: Molecular Analysis and Structure-Function Implications

Murine Major Histocompatibility Complex Class-I Mutants: Molecular Analysis and... A span of 50 years separates us from the original description of the genetic region termed H-2, which was found to control transplant rejection in mice (1, 2). The transplantation genes are now known to be part of the major histocompatibility complex (MHC), a multigene cluster located on chro­ mosome 17. At present, at least three major gene families-classes I, II, and III-occupy the H-2 region. The class-I genes encode the classical transplantation antigens, H-2Kl, H-2D, and H-2L (called K, D, and L), and the differentiation markers, Qa and TL . Class-II genes encode Ia products, involved in antigen presentation to T cells, and the class-III genes encode certain components of complement (see 3). The H-2 K, D, and L genes each determine a 45,000 Mr glycoprotein (the MHC heavy chain) that is associated noncovalently with an 11,600 Mr light-chain subunit (f32 microglobulin). These two entities, existing as a heterodimeric unit in a 1: 1 relationship, comprise the classical H-2 transplantation antigen (4, 5) (see Figure 1). The heavy chain that anchors 1 Genetic designations for the H-2 locus depict the gene in capital letters and the particular haplotype as lower case superscripts, e.g. the K gene of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Immunology Annual Reviews

Murine Major Histocompatibility Complex Class-I Mutants: Molecular Analysis and Structure-Function Implications

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Publisher
Annual Reviews
Copyright
Copyright 1986 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0732-0582
eISSN
1545-3278
DOI
10.1146/annurev.iy.04.040186.002351
pmid
3518748
Publisher site
See Article on Publisher Site

Abstract

A span of 50 years separates us from the original description of the genetic region termed H-2, which was found to control transplant rejection in mice (1, 2). The transplantation genes are now known to be part of the major histocompatibility complex (MHC), a multigene cluster located on chro­ mosome 17. At present, at least three major gene families-classes I, II, and III-occupy the H-2 region. The class-I genes encode the classical transplantation antigens, H-2Kl, H-2D, and H-2L (called K, D, and L), and the differentiation markers, Qa and TL . Class-II genes encode Ia products, involved in antigen presentation to T cells, and the class-III genes encode certain components of complement (see 3). The H-2 K, D, and L genes each determine a 45,000 Mr glycoprotein (the MHC heavy chain) that is associated noncovalently with an 11,600 Mr light-chain subunit (f32 microglobulin). These two entities, existing as a heterodimeric unit in a 1: 1 relationship, comprise the classical H-2 transplantation antigen (4, 5) (see Figure 1). The heavy chain that anchors 1 Genetic designations for the H-2 locus depict the gene in capital letters and the particular haplotype as lower case superscripts, e.g. the K gene of

Journal

Annual Review of Immunology – Annual Reviews

Published: Apr 1, 1986

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