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Opioid Peptides and Opioid Receptors in Cells of the Immune System

Opioid Peptides and Opioid Receptors in Cells of the Immune System Numerous opioid peptides are encoded by three different genes (1-5). Four types of opioid receptor (/1, D, K, e) have been clearly identified but have I Abbreviations used: ACTH, adrenocorticotropic hormone; ADCC, antibody-dependent K cellular cytotoxicity; Bma.. total number of binding sites; BREM, bremazocine, an agonist with modest selectivity for sites; CCK, cholecystokinin; ConA, concanavalin A; DADLE, [D-Ala2,D-LeuS]enkephalin, an agonist somewhat selective for /j �ites; DEX, dextrorphan, inert enantiomer of LEV; DHM, dihydromorphine, a Jl-selective agonist; DIP, dipre­ norphine, a relatively nonselective antagonist; DYN, dynorphin, a peptide product of the dynorphin gene, selective for modest selectivity for for e K K sites; EKC, ethylketazocine, a benzomorphan agonist with sites; END, endorphin; a peptide product of the pro-opio­ melanocortin gene; DADLE BREM»MOR = DYN >levallorphan> 58 59 122 h,PMNL h,PMNL h,ConAstimulated mono 60 h,leuko enhanced chemotaxis to fMLP change of cell shape inhibit production of T-lympho chemotactic factor chemotaxis IX-gliadin PEND>LEV PEND,MENK PEND Macrophage and granulocyte activity 62 r,peritoneal Mcf> 63 r, peritoneal Mcf> increased ADCC, superoxide production,cGMP increased Na MENK & Ca MENK flux, cGMP,cAMP increased superoxide production enhanced IFNy production by ConAstimulated cells PEND,MENK DYN>PEND>MOR h,PMNL, peritoneal Mcf> h,PBMNC h,PMNL inhibition offMLPstimulated superoxide production LENK,MENK m,peritoneal Mcf> http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Immunology Annual Reviews

Opioid Peptides and Opioid Receptors in Cells of the Immune System

Sibinga, N E S; Goldstein, A
Annual Review of Immunology , Volume 6 (1) – Apr 1, 1988
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Publisher
Annual Reviews
Copyright
Copyright 1988 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0732-0582
eISSN
1545-3278
DOI
10.1146/annurev.iy.06.040188.001251
pmid
2838048
Publisher site
See Article on Publisher Site

Abstract

Numerous opioid peptides are encoded by three different genes (1-5). Four types of opioid receptor (/1, D, K, e) have been clearly identified but have I Abbreviations used: ACTH, adrenocorticotropic hormone; ADCC, antibody-dependent K cellular cytotoxicity; Bma.. total number of binding sites; BREM, bremazocine, an agonist with modest selectivity for sites; CCK, cholecystokinin; ConA, concanavalin A; DADLE, [D-Ala2,D-LeuS]enkephalin, an agonist somewhat selective for /j �ites; DEX, dextrorphan, inert enantiomer of LEV; DHM, dihydromorphine, a Jl-selective agonist; DIP, dipre­ norphine, a relatively nonselective antagonist; DYN, dynorphin, a peptide product of the dynorphin gene, selective for modest selectivity for for e K K sites; EKC, ethylketazocine, a benzomorphan agonist with sites; END, endorphin; a peptide product of the pro-opio­ melanocortin gene; DADLE BREM»MOR = DYN >levallorphan> 58 59 122 h,PMNL h,PMNL h,ConAstimulated mono 60 h,leuko enhanced chemotaxis to fMLP change of cell shape inhibit production of T-lympho chemotactic factor chemotaxis IX-gliadin PEND>LEV PEND,MENK PEND Macrophage and granulocyte activity 62 r,peritoneal Mcf> 63 r, peritoneal Mcf> increased ADCC, superoxide production,cGMP increased Na MENK & Ca MENK flux, cGMP,cAMP increased superoxide production enhanced IFNy production by ConAstimulated cells PEND,MENK DYN>PEND>MOR h,PMNL, peritoneal Mcf> h,PBMNC h,PMNL inhibition offMLPstimulated superoxide production LENK,MENK m,peritoneal Mcf>

Journal

Annual Review of Immunology – Annual Reviews

Published: Apr 1, 1988

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