Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Pharmacokinetics of Drug Disposition: Hemodynamic Considerations

Pharmacokinetics of Drug Disposition: Hemodynamic Considerations G. R. Wilkinson Department of Pharmacology. Vanderbilt University. Nashville. Tennessee 37232 .,.6608 Over the past several years. the quantitative study of the time course of drug absorption. distribution. metabolism. and excretion has become an important and valuable tool in the study of the characteristics of drug action. and several phar­ macokinetic texts (1-9) have become available since Wagner's review covering the literature up to 1966 (10). Because of the complexities of biological systems from the subcellular level to the entire organism. the mathematical approaches for study­ ing the processes of drug disposition have been a compromise between hopeless complexity and oversimplification. With few exceptions. most investigators have used compartmental analysis. conceiving the body to consist of kinetically distinct compartments interconnected by. usually first-order. mass transfer constants. From a purely descriptive standpoint such an approach is frequently satisfying but. unfor­ tunately. such empirical techniques reveal little of the underlying biological factors that control the relationship(s) between the measured input and output functions after drug administration. It is readily apparent. however. that the body is nonsta­ tionary; its response to a given input changes from moment to moment and may be modified by many factors including physiological. drug. and disease http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Pharmacology and Toxicology Annual Reviews

Pharmacokinetics of Drug Disposition: Hemodynamic Considerations

Download PDF
17 pages

Loading next page...
 
/lp/annual-reviews/pharmacokinetics-of-drug-disposition-hemodynamic-considerations-yts0c9nLdV
Publisher
Annual Reviews
Copyright
Copyright 1975 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0362-1642
eISSN
1545-4304
DOI
10.1146/annurev.pa.15.040175.000303
pmid
1096786
Publisher site
See Article on Publisher Site

Abstract

G. R. Wilkinson Department of Pharmacology. Vanderbilt University. Nashville. Tennessee 37232 .,.6608 Over the past several years. the quantitative study of the time course of drug absorption. distribution. metabolism. and excretion has become an important and valuable tool in the study of the characteristics of drug action. and several phar­ macokinetic texts (1-9) have become available since Wagner's review covering the literature up to 1966 (10). Because of the complexities of biological systems from the subcellular level to the entire organism. the mathematical approaches for study­ ing the processes of drug disposition have been a compromise between hopeless complexity and oversimplification. With few exceptions. most investigators have used compartmental analysis. conceiving the body to consist of kinetically distinct compartments interconnected by. usually first-order. mass transfer constants. From a purely descriptive standpoint such an approach is frequently satisfying but. unfor­ tunately. such empirical techniques reveal little of the underlying biological factors that control the relationship(s) between the measured input and output functions after drug administration. It is readily apparent. however. that the body is nonsta­ tionary; its response to a given input changes from moment to moment and may be modified by many factors including physiological. drug. and disease

Journal

Annual Review of Pharmacology and Toxicology – Annual Reviews

Published: Apr 1, 1975

There are no references for this article.