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Pharmacology of the Autonomic Nervous System

Pharmacology of the Autonomic Nervous System By ROBERT L. VOLLE3.4 Department of Pharmacology, School of Medicine, University of Pennsylvania, Philadelphia, Pa. This review is concerned chiefly with the pharmacological aspects of synaptic transmission at various junctional sites in the peripheral autonomic nervous system. Included are a survey of recent findings concerning the interactions of drugs with receptor sites on electrogenic membranes, the effects of chemical agents on the synthesis, storage and release of transmitter agents, and the effects of drugs on the mechanisms involved in the termina­ tion of transmitter action. TRANSMISSION IN AUTONOMIC GANGLIA According to the prevailing concept of transmission in autonomic ganglia, the invasion of the preganglionic nerve terminals by the nerve impulse effects the liberation of ACh which, in turn, diffuses across the synaptic cleft and impinges upon postsynaptic elements to initiate electrical activity. Al though there is no reason for challenging this concept of transmission, recent studies from several laboratories have emerged which underscore the complexities of the process. Presynaptic site of action of drugs. In a general proposal concerning the action of ACh on various sensory and motor junctions, Koelle (1, 2) has suggested that ACh liberated endogenously from the nerve endings of the superior cervical ganglion during http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Pharmacology and Toxicology Annual Reviews

Pharmacology of the Autonomic Nervous System

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Publisher
Annual Reviews
Copyright
Copyright 1963 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0362-1642
eISSN
1545-4304
DOI
10.1146/annurev.pa.03.040163.001021
Publisher site
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Abstract

By ROBERT L. VOLLE3.4 Department of Pharmacology, School of Medicine, University of Pennsylvania, Philadelphia, Pa. This review is concerned chiefly with the pharmacological aspects of synaptic transmission at various junctional sites in the peripheral autonomic nervous system. Included are a survey of recent findings concerning the interactions of drugs with receptor sites on electrogenic membranes, the effects of chemical agents on the synthesis, storage and release of transmitter agents, and the effects of drugs on the mechanisms involved in the termina­ tion of transmitter action. TRANSMISSION IN AUTONOMIC GANGLIA According to the prevailing concept of transmission in autonomic ganglia, the invasion of the preganglionic nerve terminals by the nerve impulse effects the liberation of ACh which, in turn, diffuses across the synaptic cleft and impinges upon postsynaptic elements to initiate electrical activity. Al though there is no reason for challenging this concept of transmission, recent studies from several laboratories have emerged which underscore the complexities of the process. Presynaptic site of action of drugs. In a general proposal concerning the action of ACh on various sensory and motor junctions, Koelle (1, 2) has suggested that ACh liberated endogenously from the nerve endings of the superior cervical ganglion during

Journal

Annual Review of Pharmacology and Toxicology – Annual Reviews

Published: Apr 1, 1963

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