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Potential Animal Models for Senile Dementia of Alzheimer's Type, with Emphasis on AF64A-Induced Cholinotoxicity

Potential Animal Models for Senile Dementia of Alzheimer's Type, with Emphasis on AF64A-Induced... A number of excellent reviews have been published over the past decade, dealing with neurotoxic substances specific for neurotransmitter systems (112). Application of a few such agents has provided new animal models for various neuropsychiatric disease states, including Parkinson's disease, Hunt­ ington's disease, Senile Dementia of Alzheimer's Type (SDAT), epilepsy, and some ataxias. These all serve as background for the subj ect of this review, which focuses on literature pertaining to ethylcholine aziridinium ion (AF64A) (e.g. 13-45). We have recently proposed this agent as a potential tool in developing an animal model for SDAT (13, 20, 26), a disease in which a central cholinergic hypofunction has been implicated (46-55). In this review, the clinical, neuropathological, and behavioral features of SDAT will first be described briefly, to enable us to evaluate the relevance of AF64A-induced cholinotoxicity in vivo as a potential animal model for SDAT. We then compare the AF64A model with other experimental models of SDAT. 0362-1642/86/0415-0161$02.00 FISHER & HANIN We provide an overview of research conducted with the AF64A-treated animal, based on published reports in the literature. Finally, we discuss the potential of the AF64A-treated animal as a model of SDAT, in light of AF64A's biological effects http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Pharmacology and Toxicology Annual Reviews

Potential Animal Models for Senile Dementia of Alzheimer's Type, with Emphasis on AF64A-Induced Cholinotoxicity

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Publisher
Annual Reviews
Copyright
Copyright 1986 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0362-1642
eISSN
1545-4304
DOI
10.1146/annurev.pa.26.040186.001113
pmid
3087271
Publisher site
See Article on Publisher Site

Abstract

A number of excellent reviews have been published over the past decade, dealing with neurotoxic substances specific for neurotransmitter systems (112). Application of a few such agents has provided new animal models for various neuropsychiatric disease states, including Parkinson's disease, Hunt­ ington's disease, Senile Dementia of Alzheimer's Type (SDAT), epilepsy, and some ataxias. These all serve as background for the subj ect of this review, which focuses on literature pertaining to ethylcholine aziridinium ion (AF64A) (e.g. 13-45). We have recently proposed this agent as a potential tool in developing an animal model for SDAT (13, 20, 26), a disease in which a central cholinergic hypofunction has been implicated (46-55). In this review, the clinical, neuropathological, and behavioral features of SDAT will first be described briefly, to enable us to evaluate the relevance of AF64A-induced cholinotoxicity in vivo as a potential animal model for SDAT. We then compare the AF64A model with other experimental models of SDAT. 0362-1642/86/0415-0161$02.00 FISHER & HANIN We provide an overview of research conducted with the AF64A-treated animal, based on published reports in the literature. Finally, we discuss the potential of the AF64A-treated animal as a model of SDAT, in light of AF64A's biological effects

Journal

Annual Review of Pharmacology and Toxicology – Annual Reviews

Published: Apr 1, 1986

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