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Primary Amebic Meningoencephalitis and the Biology of Naegleria Fowleri

Primary Amebic Meningoencephalitis and the Biology of Naegleria Fowleri Primary amebic meningoencephalitis (PAM) is a rapidly fatal human dis­ ease caus(:d by the ameboflagellate Naegleria fowleri. The disease first was detected in man 17 years ago by Fowler & Carter in Australia (56). A year later in 1966 three fatal infections were described from Florida by Butt (10). 101 0066-4227/82/1001-0101$02.00 JOHN The symptomatology of these cases was remarkably similar to that observed in Australia. Although it was not apparent then, the seven cases in Australia and Florida provided almost a complete array of the important clinical and pathological features of the disease. Notable, also, was the indication that infection was acquired by intrana­ sal instillation during swimming. Butt (10) recognized the discovery of a new disease in Australia and Florida by contributing a new name, primary amebic meningoencephalitis. Naegleria fowleri was named in honor of Dr. Malcom Fowler who first recognized the disease it caused (13) . This has been the only species of Naegleria to be isolated from victims of PAM. Synonyms for N fowleri are N aerobia (114) and N. invades (24) . Nonpathogenic species of Naegleria include N. gruberi (see 58) , possibly the most common ameba in fresh water (101) , N. thorn http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Microbiology Annual Reviews

Primary Amebic Meningoencephalitis and the Biology of Naegleria Fowleri

John, D T
Annual Review of Microbiology , Volume 36 (1) – Oct 1, 1982
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23 pages

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Publisher
Annual Reviews
Copyright
Copyright 1982 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0066-4227
eISSN
1545-3251
DOI
10.1146/annurev.mi.36.100182.000533
pmid
6756287
Publisher site
See Article on Publisher Site

Abstract

Primary amebic meningoencephalitis (PAM) is a rapidly fatal human dis­ ease caus(:d by the ameboflagellate Naegleria fowleri. The disease first was detected in man 17 years ago by Fowler & Carter in Australia (56). A year later in 1966 three fatal infections were described from Florida by Butt (10). 101 0066-4227/82/1001-0101$02.00 JOHN The symptomatology of these cases was remarkably similar to that observed in Australia. Although it was not apparent then, the seven cases in Australia and Florida provided almost a complete array of the important clinical and pathological features of the disease. Notable, also, was the indication that infection was acquired by intrana­ sal instillation during swimming. Butt (10) recognized the discovery of a new disease in Australia and Florida by contributing a new name, primary amebic meningoencephalitis. Naegleria fowleri was named in honor of Dr. Malcom Fowler who first recognized the disease it caused (13) . This has been the only species of Naegleria to be isolated from victims of PAM. Synonyms for N fowleri are N aerobia (114) and N. invades (24) . Nonpathogenic species of Naegleria include N. gruberi (see 58) , possibly the most common ameba in fresh water (101) , N. thorn

Journal

Annual Review of Microbiology – Annual Reviews

Published: Oct 1, 1982

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