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Regulation of B-Cell Differentiation: Interactions of Factors and Corresponding Receptors

Regulation of B-Cell Differentiation: Interactions of Factors and Corresponding Receptors The antibody response to nominal antigen such as hapten-carrier con­ jugates involves the cooperation of hapten-specific B cells and carrier­ specific helper T cells (1-4). In addition to the carrier specificity, helper T cells recognize determinants encoded by genes in the class-II major histocompatibility complex (MHC) on antigen-presenting cells as well as on B cells (5-13). The interaction between helper T cells and antigen­ presenting accessory cells (APC) is genetically restricted by products of the major histocompatibility complex (14-16). However, the cellular interac­ tions between helper T cells and B cells have been reported as restricted by self-MHC products (5-7, 10-12, 1 7) or not restricted by the MHC elements (18, 19). Since genetic restrictions imposed by products of the MHC are considered as a requirement for the recognition by T cells of self-MHC determinants expressed by non-T cells (APC), this controversy can be explained on the basis of whether T cells must necessarily recognize the MHC determinants expressed by B cells in order to trigger them to secrete antibodies. Since the original description of a role for T cells in the antigen­ dependent stimulation of B cells, a great deal of effort has gone toward elucidating the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Immunology Annual Reviews

Regulation of B-Cell Differentiation: Interactions of Factors and Corresponding Receptors

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Publisher
Annual Reviews
Copyright
Copyright 1986 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0732-0582
eISSN
1545-3278
DOI
10.1146/annurev.iy.04.040186.001123
pmid
2939856
Publisher site
See Article on Publisher Site

Abstract

The antibody response to nominal antigen such as hapten-carrier con­ jugates involves the cooperation of hapten-specific B cells and carrier­ specific helper T cells (1-4). In addition to the carrier specificity, helper T cells recognize determinants encoded by genes in the class-II major histocompatibility complex (MHC) on antigen-presenting cells as well as on B cells (5-13). The interaction between helper T cells and antigen­ presenting accessory cells (APC) is genetically restricted by products of the major histocompatibility complex (14-16). However, the cellular interac­ tions between helper T cells and B cells have been reported as restricted by self-MHC products (5-7, 10-12, 1 7) or not restricted by the MHC elements (18, 19). Since genetic restrictions imposed by products of the MHC are considered as a requirement for the recognition by T cells of self-MHC determinants expressed by non-T cells (APC), this controversy can be explained on the basis of whether T cells must necessarily recognize the MHC determinants expressed by B cells in order to trigger them to secrete antibodies. Since the original description of a role for T cells in the antigen­ dependent stimulation of B cells, a great deal of effort has gone toward elucidating the

Journal

Annual Review of Immunology – Annual Reviews

Published: Apr 1, 1986

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