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Regulation of IgE Synthesis

Regulation of IgE Synthesis The IgE antibody response to protein antigens shares mechanisms with the IgM and IgC antibody responses to T-dependent antigens. However, the IgE response in experimental animals has several characteristics not easily dem­ onstrated in the IgG response. The IgE antibody response is obtained under restricted conditions and is highly dependent on the adjuvant employed. Bor­ detella pertussis vaccine (BP) and aluminum hydroxide gel (alum) are effec­ tive adjuvants for the IgE antibody response, while complete Freund's adjuvant (CFA) is less effective. Even when a high-responder mouse strain is immu­ nized with a potent immunogen together with an appropriate adjuvant, an increase in the dose of immunogen makes the IgE antibody response transient and causes a dissociation between the IgG and IgE antibody responses ( 1 ). Thus, a persistent IgE antibody response is obtained only when a high-responder strain is immunized with a minute dose of a potent immunogen together with an appropriate adjuvant. The IgE response is controlled not only by Ir-genes but also by another gene. Some strains, such as SJL, cannot form IgE antibodies to conventional antigens, in spite of a substantial IgG antibody response (2). Breeding exper­ iments showed that this genetic control is http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Immunology Annual Reviews

Regulation of IgE Synthesis

Ishizaka, K
Annual Review of Immunology , Volume 2 (1) – Apr 1, 1984
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Publisher
Annual Reviews
Copyright
Copyright 1984 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0732-0582
eISSN
1545-3278
DOI
10.1146/annurev.iy.02.040184.001111
pmid
6085750
Publisher site
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Abstract

The IgE antibody response to protein antigens shares mechanisms with the IgM and IgC antibody responses to T-dependent antigens. However, the IgE response in experimental animals has several characteristics not easily dem­ onstrated in the IgG response. The IgE antibody response is obtained under restricted conditions and is highly dependent on the adjuvant employed. Bor­ detella pertussis vaccine (BP) and aluminum hydroxide gel (alum) are effec­ tive adjuvants for the IgE antibody response, while complete Freund's adjuvant (CFA) is less effective. Even when a high-responder mouse strain is immu­ nized with a potent immunogen together with an appropriate adjuvant, an increase in the dose of immunogen makes the IgE antibody response transient and causes a dissociation between the IgG and IgE antibody responses ( 1 ). Thus, a persistent IgE antibody response is obtained only when a high-responder strain is immunized with a minute dose of a potent immunogen together with an appropriate adjuvant. The IgE response is controlled not only by Ir-genes but also by another gene. Some strains, such as SJL, cannot form IgE antibodies to conventional antigens, in spite of a substantial IgG antibody response (2). Breeding exper­ iments showed that this genetic control is

Journal

Annual Review of Immunology – Annual Reviews

Published: Apr 1, 1984

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