Access the full text.
Sign up today, get DeepDyve free for 14 days.
J. Durdik, M. Moore, E. Selsing (1984)Novel κ light-chain gene rearrangements in mouse λ light chain-producing B lymphocytes
D. Loh, A. Bothwell, M. White-Scharf, T. Imanishi‐Kari, D. Baltimore (1983)Molecular basis of a mouse strain-specific anti-hapten response
M. Steinmetz, W. Altenburger, H. Zachau (1980)A rearranged DNA sequence possibly related to the translocation of immunoglobulin gene segments.
Nucleic acids research, 8 8
H. Benjamin, M. Matzuk, M. Krasnow, N. Cozzarelli (1985)Recombination site selection by Tn3 resolvase: Topological tests of a tracking mechanism
Y. Bergman, D. Rice, R. Grosschedl, D. Baltimore (1984)Two regulatory elements for immunoglobulin kappa light chain gene expression.
Proceedings of the National Academy of Sciences of the United States of America, 81 22
C. Coleclough (1983)Chance, necessity and antibody gene dynamics
V. Bohr, C. Smith, D. Okumoto, P. Hanawalt (1985)DNA repair in an active gene: Removal of pyrimidine dimers from the DHFR gene of CHO cells is much more efficient than in the genome overall
R. Grosschedl, D. Weaver, D. Baltimore, F. Costantini (1984)Introduction of a μ immunoglobulin gene into the mouse germ line: Specific expression in lymphoid cells and synthesis of functional antibody
G. Siu, S. Clark, Y. Yoshikai, M. Malissen, Y. Yanagi, E. Strauss, T. Mak, L. Hood (1984)The human t cell antigen receptor is encoded by variable, diversity, and joining gene segments that rearrange to generate a complete V gene
Barbara Baumann, M. Potash, Georges Kohlerl (1985)Consequences of frameshift mutations at the immunoglobulin heavy chain locus of the mouse.
The EMBO Journal, 4
A. Klar, J. Strathern, J. Abraham (1984)Involvement of double-strand chromosomal breaks for mating-type switching in Saccharomyces cerevisiae.
Cold Spring Harbor symposia on quantitative biology, 49
S. Cory, B. Tyler, J. Adams (1981)Sets of immunoglobulin V kappa genes homologous to ten cloned V kappa sequences: implications for the number of germline V kappa genes.
Journal of molecular and applied genetics, 1 2
G. Yancopoulos, F. Alt (1985)Developmentally controlled and tissue-specific expression of unrearranged VH gene segments
F. Alt, G. Yancopoulos, T. Blackwell, C. Wood, E. Thomas, M. Boss, R. Coffman, N. Rosenberg, S. Tonegawa, D. Baltimore (1984)Ordered rearrangement of immunoglobulin heavy chain variable region segments.
The EMBO Journal, 3
P. Early, Henry Huang, Mark Davis, K. Calame, Leroy Hood (1980)An immunoglobulin heavy chain variable region gene is generated from three segments of DNA: VH, D and JH
H. Sakano, K. Hüppi, G. Heinrich, S. Tonegawa (1979)Sequences at the somatic recombination sites of immunoglobulin light-chain genes
H. Snodgrass, Z. Dembić, M. Steinmetz, H. Boehmer (1985)Expression of T-cell antigen receptor genes during fetal development in the thymus
D. Swan, P. D’Eustachio, L. Leinwand, J. Seidman, D. Keithley, F. Ruddle (1979)Chromosomal assignment of the mouse kappa light chain genes.
Proceedings of the National Academy of Sciences of the United States of America, 76 6
K. Siminovitch, A. Bakhshi, P. Goldman, S. Korsmeyer (1985)A uniform deleting element mediates the loss of κ genes in human B cells
Kindred Ritchie, R. Brinster, U. Storb (1984)Allelic exclusion and control of endogenous immunoglobulin gene rearrangement in κ transgenic mice
S. Kwan, E. Max, J. Seidman, P. Leder, M. Scharff (1981)Two kappa immunoglobulin genes are expressed in the myeloma S107
T. Parslow, D. Blair, W. Murphy, D. Granner (1984)Structure of the 5' ends of immunoglobulin genes: a novel conserved sequence.
Proceedings of the National Academy of Sciences of the United States of America, 81 9
D. Picard, W. Schaffner (1984)A lymphocyte-specific enhancer in the mouse immunoglobulin κ gene
S. Lewis, A. Gifford, D. Baltimore (1984)Joining of VK to JK gene segments in a retroviral vector introduced into lymphoid cells
T. Eickbush, F. Kafatos (1982)A walk in the chorion locus of bombyx mori
E. Siden, F. Alt, L. Shinefeld, V. Sato, D. Baltimore (1981)Synthesis of immunoglobulin mu chain gene products precedes synthesis of light chains during B-lymphocyte development.
Proceedings of the National Academy of Sciences of the United States of America, 78 3
Y. Chien, N. Gascoigne, J. Kavaler, N. Lee, Mark Davis (1984)Somatic recombination in a murine T-cell receptor gene
O. Bernard, N. Gough, J. Adams (1981)Plasmacytomas with more than one immunoglobulin kappa mRNA: implications for allelic exclusion.
Proceedings of the National Academy of Sciences of the United States of America, 78 9
J. Kavaler, Mark Davis, Y. Chien (1984)Localization of a T-cell receptor diversity-region element
P. Brodeur, R. Riblet (1984)The immunoglobulin heavy chain variable region (Igh‐V) locus in the mouse. I. One hundred Igh‐V genes comprise seven families of homologous genes
European Journal of Immunology, 14
S. Lewis, N. Rosenberg, F. Alt, D. Baltimore (1982)Continuing kappa-gene rearrangement in a cell line transformed by Abelson murine leukemia virus
E. Selsing, U. Storb (1981)Mapping of immunoglobulin variable region genes: relationship to the 'deletion' model of immunoglobulin gene rearrangement.
Nucleic acids research, 9 21
P. D'EUSTACHIO, Dimitrina Pravtcheva, Kenneth Marcu (1980)Chromosomal location of the structural gene cluster encoding murine immunoglobulin heavy chains
The Journal of Experimental Medicine, 151
M. Reth, P. Ammirati, S. Jackson, F. Alt (1985)Regulated progression of a cultured pre-B-cell line to the B-cell stage
Tohru Kataoka, Sigeru Kondo, Miyuki Nishi, Mieko Kodaira, Tasuku Honjo (1984)Isolation and characterization of endonuclease J: a sequence-specific endonuclease cleaving immunoglobulin genes.
Nucleic acids research, 12 15
J. Banerji, L. Olson, W. Schaffner (1983)A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes
R. Maki, J. Kearney, C. Paige, S. Tonegawa (1980)Immunoglobulin gene rearrangement in immature B cells.
Science, 209 4463
T. Blackwell, F. Alt (1984)Site-specific recombination between immunoglobulin D and JH segments that were introduced into the genome of a murine pre-B cell line
D. Kemp, A. Harris, S. Cory, J. Adams (1980)Expression of the immunoglobulin C mu gene in mouse T and B lymphoid and myeloid cell lines.
Proceedings of the National Academy of Sciences of the United States of America, 77 5
R. Perlmutter, J. Kearney, S. Chang, L. Hood (1985)Developmentally controlled expression of immunoglobulin VH genes.
Science, 227 4694
H. Sakano, Y. Kurosawa, M. Weigert, S. Tonegawa (1981)Identification and nucleotide sequence of a diversity DNA segment (D) of immunoglobulin heavy-chain genes
S. Desiderio, D. Baltimore (1984)Double-stranded cleavage by cell extracts near recombinational signal sequences of immunoglobulin genes
D. Levitt, M. Cooper (1980)Mouse pre-B cells synthesize and secrete μ heavy chains but not light chains
R. Grosschedl, D. Whitehead (1985)Cell-type specificity of iminunoglobulin gene expression is regulated by at least three DNA sequence elements
G. Yancopoulos, P. Nisen, A. Tesfaye, N. Kohl, M. Goldfarb, F. Alt (1985)N-myc can cooperate with ras to transform normal cells in culture.
Proceedings of the National Academy of Sciences of the United States of America, 82 16
R. Kahmann, F. Rudt, C. Koch, G. Mertens (1985)G inversion in bacteriophage Mu DNA is stimulated by a site within the invertase gene and a host factor
S. Desiderio, G. Yancopoulos, M. Paskind, E. Thomas, M. Boss, N. Landau, F. Alt, D. Baltimore (1984)Insertion of N regions into heavy-chain genes is correlated with expression of terminal deoxytransferase in B cells
S. Klein, F. Sablitzky, Andreas Radbruch (1984)Deletion of the IgH enhancer does not reduce immunoglobulin heavy chain production of a hybridoma IgD class switch variant.
The EMBO Journal, 3
H. Eisen, E. Reilly (1985)Lambda chains and genes in inbred mice.
Annual review of immunology, 3
P. Burrows, G. Beck, M. Wabl (1981)Expression of mu and gamma immunoglobulin heavy chains in different cells of a cloned mouse lymphoid line.
Proceedings of the National Academy of Sciences of the United States of America, 78 1
M. Wabl, C. Steinberg (1982)A theory of allelic and isotypic exclusion for immunoglobulin genes.
Proceedings of the National Academy of Sciences of the United States of America, 79 22
Falko Falkner, Hans Zachau (1984)Correct transcription of an immunoglobulin κ gene requires an upstream fragment containing conserved sequence elements
H. Sugiyama, S. Akira, H. Kikutani, S. Kishimoto, Y. Yamamura, T. Kishimoto (1983)Functional V region formation during in vitro culture of a murine immature B precursor cell line
S. Tonegawa (1983)Somatic generation of antibody diversity
M. Wabl, P. Burrows (1984)Expression of immunoglobulin heavy chain at a high level in the absence of a proposed immunoglobulin enhancer element in cis.
Proceedings of the National Academy of Sciences of the United States of America, 81 8
B. Cebra, Ph D, J. Colberg, A. Dray (1966)RABBIT LYMPHOID CELLS DIFFERENTIATED WITH RESPECT TO α-, γ-, AND µ- HEAVY POLYPEPTIDE CHAINS AND TO ALLOTYPIC MARKERS AA1 AND AA2
The Journal of Experimental Medicine, 123
F. Alt, V. Enea, A. Bothwell, D. Baltimore (1980)Activity of multiple light chain genes in murine myeloma cells producing a single, functional light chain
E. Max, J. Seidman, P. Leder (1979)Sequences of five potential recombination sites encoded close to an immunoglobulin kappa constant region gene.
Proceedings of the National Academy of Sciences of the United States of America, 76 7
G. Siu, M. Kronenberg, E. Strauss, R. Haars, T. Mak, L. Hood (1984)The structure, rearrangement and expression of Dβ gene segments of the murine T-cell antigen receptor
S. Gillies, S. Morrison, V. Oi, S. Tonegawa (1983)A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene
S. Akira, H. Sugiyama, N. Yoshida, H. Kikutani, Y. Yamamura, T. Kishimoto (1983)Isotype switching in murine pre-B cell lines
M. Neuberger (1983)Expression and regulation of immunoglobulin heavy chain gene transfected into lymphoid cells.
The EMBO Journal, 2
J. Mason, G. Williams, M. Neuberger (1985)Transcription cell type specificity is conferred by an immunoglobulin VH gene promoter that includes a functional consensus sequence
Y. Kurosawa, H. Boehmer, W. Haas, H. Sakano, André Trauneker, S. Tonegawa (1981)Identification of D segments of immunoglobulin heavy-chain genes and their rearrangement in T lymphocytes
E. Siden, D. Baltimore, D. Clark, N. Rosenberg (1979)Immunoglobulin synthesis by lymphoid cells transformed in vitro by Abelson murine leukemia virus
B. Pernis, G. Chiappino, A. Kelus, P. Gell (1965)CELLULAR LOCALIZATION OF IMMUNOGLOBULINS WITH DIFFERENT ALLOTYPIC SPECIFICITIES IN RABBIT LYMPHOID TISSUES
The Journal of Experimental Medicine, 122
R. Coffman, I. Weissman (1983)Immunoglobulin gene rearrangement during pre-B cell differentiation.
The Journal of molecular and cellular immunology : JMCI, 1 1
J. Höchtl, H. Zachau (1983)A novel type of aberrant recombination in immunoglobulin genes and its implications for V–J joining mechanism
M. Reth, F. Alt (1984)Novel immunoglobulin heavy chains are produced from DJH gene segment rearrangements in lymphoid cells
F. Alt, D. Baltimore (1982)Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions.
Proceedings of the National Academy of Sciences of the United States of America, 79 13
F. Alt, N. Rosenberg, V. Enea, E. Siden, D. Baltimore (1982)Multiple immunoglobulin heavy-chain gene transcripts in Abelson murine leukemia virus-transformed lymphoid cell lines
Molecular and Cellular Biology, 2
Oliver Smithies, M. Poulik (1972)Initiation of Protein Synthesis at an Unusual Position in an Immunoglobulin Gene?
During the past several years, it has become increasingly evident that the regulation of immunoglobulin (Ig) gene assembly and expression is intrinsically related to the progression of B-cell precursors to the B-cell differentiation stage. The general focus of this review is to describe in detail the mechanism of Ig variable-region gene assembly and to explore the possible regulatory mechanisms that the cell exploits to control these genomic rearrangement events. Because assembly of the variable region of the T-cell antigen-receptor genes appears to be mediated by the same molecular elements, the general principles we describe should apply to both Ig and T cell-receptor variable-region genes. The immune system is capable of responding to an almost infinite number of antigenic challenges by producing a tremendous diversity of antibody specificities. Each antibody molecule consists of heavy (H) and light (L) immunoglobulin polypeptide chains. The carboxy terminus of H and L chains is a region of constant amino acid sequence. The constant region of the H chain is involved in a variety of effector functions, such as Fe-receptor binding and complement fixation. The amino terminus of both these chains contains a region of variable amino acid sequences (designated the variable region) that
Annual Review of Immunology – Annual Reviews
Published: Apr 1, 1986
Access the full text.
Sign up today, get DeepDyve free for 14 days.