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/lp/annual-reviews/renal-calcium-metabolism-and-diuretics-Qoz6oF6gQd
- Publisher
- Annual Reviews
- Copyright
- Copyright 1986 Annual Reviews. All rights reserved
- Subject
- Review Articles
- ISSN
- 0362-1642
- eISSN
- 1545-4304
- DOI
- 10.1146/annurev.pa.26.040186.000533
- pmid
- 3521452
- Publisher site
- See Article on Publisher Site
Abstract
The major purposes of diuretics are to enhance renal excretion of salt and water and to lower blood pressure. However, their effects are not limited to sodium and chloride; they may also influence the renal reabsorption and excretion of calcium, magnesium, potassium, and other ions. It is important to be aware of these effects in order to maintain appropriate body content of essential chemi cals. The present review centers on the interactions of diuretic agents with calcium. Knowledge of these interactions may be useful in the appropriate application of diuretic agents for the maintenance of normal blood con centrations and body stores of calcium, especially during the chronic use of diuretic agents. Also, diuretic agents with differing effects on calcium metabo lism may be indicated therapeutically in disorders of calcium metabolism. In the present review, we have taken into account the effects of diuretic agents on renal calcium metabolism relative to hormonal and nonhormonal factors and their direct actions within the nephron. Several excellent reviews of diuretics have been published in the past few years (1-3). CALCIUM HANDLING BY THE KIDNEY Filtration and Reabsorption Calcium is present in plasma in three forms: free calcium, calcium anionic complexes, and
Journal
Annual Review of Pharmacology and Toxicology – Annual Reviews
Published: Apr 1, 1986