Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/annual-reviews/signaling-by-antibodies-recent-progress-KJepstV26i
- Publisher
- Annual Reviews
- Copyright
- Copyright © 2017 by Annual Reviews. All rights reserved
- ISSN
- 0732-0582
- eISSN
- 1545-3278
- DOI
- 10.1146/annurev-immunol-051116-052433
- pmid
- 28446061
- Publisher site
- See Article on Publisher Site
Abstract
IgG antibodies mediate a diversity of immune functions by coupling of antigen specificity through the Fab domain to signal transduction via Fc-Fc receptor interactions. Indeed, balanced IgG signaling through type I and type II Fc receptors is required for the control of proinflammatory, anti-inflammatory, and immunomodulatory processes. In this review, we discuss the mechanisms that govern IgG–Fc receptor interactions, highlighting the diversity of Fc receptor–mediated effector functions that regulate immunity and inflammation as well as determine susceptibility to infection and autoimmunity and responsiveness to antibody-based therapeutics and vaccines.
Journal
Annual Review of Immunology – Annual Reviews
Published: Apr 26, 2017