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SYNAPTIC MECHANISMS FOR CODING TIMING IN AUDITORY NEURONS

SYNAPTIC MECHANISMS FOR CODING TIMING IN AUDITORY NEURONS ▪ Abstract Neurons in the cochlear ganglion and auditory brain stem nuclei preserve the relative timing of action potentials passed through sequential synaptic levels. To accomplish this task, these neurons have unique morphological and biophysical specializations in axons, dendrites, and nerve terminals. At the membrane level, these adaptations include low-threshold, voltage-gated potassium channels and unusually rapid-acting transmitter-gated channels, which govern how quickly and reliably action potential threshold is reached during a synaptic response. Some nerve terminals are remarkably large and release large amounts of excitatory neurotransmitter. The high output of transmitter at these terminals can lead to synaptic depression, which may itself be regulated by presynaptic transmitter receptors. The way in which these different cellular mechanisms are employed varies in different cell types and circuits and reflects refinements suited to different aspects of acoustic processing. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Physiology Annual Reviews

SYNAPTIC MECHANISMS FOR CODING TIMING IN AUDITORY NEURONS

Annual Review of Physiology , Volume 61 (1) – Mar 1, 1999

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Publisher
Annual Reviews
Copyright
Copyright © 1999 by Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0066-4278
eISSN
1545-1585
DOI
10.1146/annurev.physiol.61.1.477
pmid
10099698
Publisher site
See Article on Publisher Site

Abstract

▪ Abstract Neurons in the cochlear ganglion and auditory brain stem nuclei preserve the relative timing of action potentials passed through sequential synaptic levels. To accomplish this task, these neurons have unique morphological and biophysical specializations in axons, dendrites, and nerve terminals. At the membrane level, these adaptations include low-threshold, voltage-gated potassium channels and unusually rapid-acting transmitter-gated channels, which govern how quickly and reliably action potential threshold is reached during a synaptic response. Some nerve terminals are remarkably large and release large amounts of excitatory neurotransmitter. The high output of transmitter at these terminals can lead to synaptic depression, which may itself be regulated by presynaptic transmitter receptors. The way in which these different cellular mechanisms are employed varies in different cell types and circuits and reflects refinements suited to different aspects of acoustic processing.

Journal

Annual Review of PhysiologyAnnual Reviews

Published: Mar 1, 1999

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