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- Publisher
- Annual Reviews
- Copyright
- Copyright 1993 Annual Reviews. All rights reserved
- Subject
- Review Articles
- ISSN
- 0732-0582
- eISSN
- 1545-3278
- DOI
- 10.1146/annurev.iy.11.040193.003351
- pmid
- 8476576
- Publisher site
- See Article on Publisher Site
Abstract
Malaria remains a leading cause of human morbidity and mortality due to the inability of insecticides and chemotherapy/chemoprophylaxis to eliminate the vectors or disease caused by this protozoan parasite. In an effort to develop new methods of control, vaccines targeted to the various stages of the complex life cycle of Plasmodium have been developed. This review describes recent advances in the elucidation of cell-mediated immune mechanisms directed against sporozoites and liver stages of malaria parasites, their role in protection, and their relation to vaccine development. Recent data on the molecular basis of sporozoite-liver cell interaction are presented, and these may provide new approaches for chemoprophylaxis and immunoprophylaxis. We describe the role of the circumsporozoite protein, the major sporozoite surface antigen, in spo rozoite movement and as a target of humoral immunity. The recognition of the circumsporozoite protein by human T cells is reviewed with emphasis on cytotoxic T cells and immune resistance against the exo-erythrocytic stage of the parasite. Earlier concepts regarding the polymorphisms of the 687 0732-0582/93/041 0-0687$02.00 NARDIN & NUSSENZWEIG circumsporozoite protein, the immunological relevance of this poly morphism, and predictions regarding vaccine development are reevaluated on the basis of recent data from different malaria endemic
Journal
Annual Review of Immunology – Annual Reviews
Published: Apr 1, 1993