Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

The Biochemistry and Cell Biology of Antigen Processing and Presentation

The Biochemistry and Cell Biology of Antigen Processing and Presentation T lymphocytes with rxf3 receptors recognize antigen in association with the polymorphic products of the class I and class II loci of the major histocompatibility complex (MHC). This presentation of antigen results from the intracellular generation of protein fragments, and the binding and transport to the cell surface of these peptides in stable association with the MHC class I and class II molecules. Each class of MHC molecule appears specialized for capture of peptides present in a particular intra­ cellular compartment. We describe here the structural basis of peptide­ MHC molecule interaction, the differences in biochemical behavior that focus the two classes of MHC molecules on peptides of distinct size and location, and the cell biology of MHC molecule transport, peptide generation, and intracellular movement. The importance of con* The US government has the right to retain a nonexclusive, royalty-free license in and to any copyright covering this paper. GERMAIN & MARGULIES formational changes accompanying peptide binding that affect subunit stability of MHC molecules, and the relationship between these changes and the handling of proteins by intracellular chaperones, are emphasized as key features in the operation of the class I and class II presentation pathways. INTRODUCTION The specificity http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Immunology Annual Reviews

The Biochemistry and Cell Biology of Antigen Processing and Presentation

Germain, R N; Margulies, D H
Annual Review of Immunology , Volume 11 (1) – Apr 1, 1993
Download PDF
48 pages

Loading next page...
 
/lp/annual-reviews/the-biochemistry-and-cell-biology-of-antigen-processing-and-hS9lr2A9L0

References (177)

Publisher
Annual Reviews
Copyright
Copyright 1993 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0732-0582
eISSN
1545-3278
DOI
10.1146/annurev.iy.11.040193.002155
pmid
8476568
Publisher site
See Article on Publisher Site

Abstract

T lymphocytes with rxf3 receptors recognize antigen in association with the polymorphic products of the class I and class II loci of the major histocompatibility complex (MHC). This presentation of antigen results from the intracellular generation of protein fragments, and the binding and transport to the cell surface of these peptides in stable association with the MHC class I and class II molecules. Each class of MHC molecule appears specialized for capture of peptides present in a particular intra­ cellular compartment. We describe here the structural basis of peptide­ MHC molecule interaction, the differences in biochemical behavior that focus the two classes of MHC molecules on peptides of distinct size and location, and the cell biology of MHC molecule transport, peptide generation, and intracellular movement. The importance of con* The US government has the right to retain a nonexclusive, royalty-free license in and to any copyright covering this paper. GERMAIN & MARGULIES formational changes accompanying peptide binding that affect subunit stability of MHC molecules, and the relationship between these changes and the handling of proteins by intracellular chaperones, are emphasized as key features in the operation of the class I and class II presentation pathways. INTRODUCTION The specificity

Journal

Annual Review of Immunology – Annual Reviews

Published: Apr 1, 1993

There are no references for this article.