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The Cell Biology of Macrophage Activation

The Cell Biology of Macrophage Activation The fundamental concept of M<\> activation dates to the observations of Elie Metchnikoff, who noted over 75 years ago that mononuclear phagocytes from animals resistant to certain bacterial infections had increased competence for ingesting and killing these microbes (1). During the 1960s, George Mackaness and his colleagues elegantly elucidated the basis of cellular immunity to facul­ tative and obligate intracellular parasites and termed "activated" the large, angry M<\> that finally effect such immunity [for reviews, see (2 ,3»). In the early 1970s, Evans & Alexander and Hibbs & Remington found that these angry M<\> were also extremely efficient at destroying neoplastic, eukaryotic cells as well [for references, see (3)] . The activated M<\> has thus come to be defined as one capable of mediating antitumor or antimicrobial effects (3). The basic cellular physiology of the M<\> has been extensively studied . Indeed, mononuclear phagocytes have proven to be a successful and widely used tool in cell biology. Since the elegant and seminal studies of Cohn and colleagues in the 1960s on the development and maturation of M<\> (4), the endocytic and regulatory receptors, the plasma membrane proteins, the secre­ tory products, and the intracellular constituents of these cells http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Immunology Annual Reviews

The Cell Biology of Macrophage Activation

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References (28)

Publisher
Annual Reviews
Copyright
Copyright 1984 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0732-0582
eISSN
1545-3278
DOI
10.1146/annurev.iy.02.040184.001435
pmid
6100475
Publisher site
See Article on Publisher Site

Abstract

The fundamental concept of M<\> activation dates to the observations of Elie Metchnikoff, who noted over 75 years ago that mononuclear phagocytes from animals resistant to certain bacterial infections had increased competence for ingesting and killing these microbes (1). During the 1960s, George Mackaness and his colleagues elegantly elucidated the basis of cellular immunity to facul­ tative and obligate intracellular parasites and termed "activated" the large, angry M<\> that finally effect such immunity [for reviews, see (2 ,3»). In the early 1970s, Evans & Alexander and Hibbs & Remington found that these angry M<\> were also extremely efficient at destroying neoplastic, eukaryotic cells as well [for references, see (3)] . The activated M<\> has thus come to be defined as one capable of mediating antitumor or antimicrobial effects (3). The basic cellular physiology of the M<\> has been extensively studied . Indeed, mononuclear phagocytes have proven to be a successful and widely used tool in cell biology. Since the elegant and seminal studies of Cohn and colleagues in the 1960s on the development and maturation of M<\> (4), the endocytic and regulatory receptors, the plasma membrane proteins, the secre­ tory products, and the intracellular constituents of these cells

Journal

Annual Review of Immunology – Annual Reviews

Published: Apr 1, 1984

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