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The Cellular Basis of Immunity

The Cellular Basis of Immunity H. TALIAFERRO Department of Bacteriology and Parasitology, University o f Chicago, Chicago, Illinois Once invading organisms or other antigenic materials have passed or have been introduced beyond the epithelial or mechani­ cal barriers, their localization and disposal is a part of local (local inflammation) and general defense reactions. The main functional roles of the cells involved in these reactions are (a) to remove foreign material by extra- or intracellular digestion (phagocytosis) or to isolate it by a connective tissue wall (encapsulation); perform various reparative processes; and (b) to (c) to produce specific antibodies. With the exception of that part of repair which involves the parenchyma, the cells involved belong almost exclusively to the connective tissue, especially to the blood and lymph, to the reticular and loose connective tissues, and to the lamina propria and interstitial connective tissues of various organs including the brain. The cells are important to varying degrees in immunity be­ cause (a) they are ubiquitous in distribution or are easily mobilized via the blood stream; (b) they are phagocytic and/or possess potent digestive enzymes; and (c) they form a mesenchymal reserve in the postnatal vertebrate by retaining varying degrees of their embryonic power to develop http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Microbiology Annual Reviews

The Cellular Basis of Immunity

Taliaferro, W H
Annual Review of Microbiology , Volume 3 (1) – Oct 1, 1949
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Publisher
Annual Reviews
Copyright
Copyright 1949 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0066-4227
eISSN
1545-3251
DOI
10.1146/annurev.mi.03.100149.001111
Publisher site
See Article on Publisher Site

Abstract

H. TALIAFERRO Department of Bacteriology and Parasitology, University o f Chicago, Chicago, Illinois Once invading organisms or other antigenic materials have passed or have been introduced beyond the epithelial or mechani­ cal barriers, their localization and disposal is a part of local (local inflammation) and general defense reactions. The main functional roles of the cells involved in these reactions are (a) to remove foreign material by extra- or intracellular digestion (phagocytosis) or to isolate it by a connective tissue wall (encapsulation); perform various reparative processes; and (b) to (c) to produce specific antibodies. With the exception of that part of repair which involves the parenchyma, the cells involved belong almost exclusively to the connective tissue, especially to the blood and lymph, to the reticular and loose connective tissues, and to the lamina propria and interstitial connective tissues of various organs including the brain. The cells are important to varying degrees in immunity be­ cause (a) they are ubiquitous in distribution or are easily mobilized via the blood stream; (b) they are phagocytic and/or possess potent digestive enzymes; and (c) they form a mesenchymal reserve in the postnatal vertebrate by retaining varying degrees of their embryonic power to develop

Journal

Annual Review of Microbiology – Annual Reviews

Published: Oct 1, 1949

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