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The Ly-49 and NKR-P1 Gene Families Encoding Lectin-Like Receptors on Natural Killer Cells: The NK Gene Complex

The Ly-49 and NKR-P1 Gene Families Encoding Lectin-Like Receptors on Natural Killer Cells: The NK... Natural killer cells lyse tumor and virally infected cells in a specific manner that has not been molecularly characterized. Target cell expression of major histocompatibility complex (MHC) class I molecules is correlated with target cell resistance to natural killing. A mechanism to explain this observation is that NK cells may display two types of recognition and activation molecules that have opposing functions when bound to target cell ligands. One type of surface receptor such as the NKR-PI molecule may activate NK activity whereas the other, represented by the mouse Ly--49 molecule, may engage target cell MHC molecules and inhibit cyto­ toxicity by transducing "negative" signals. NKR-Pl and Ly--49 are struc­ turally related, and they are encoded by genetically linked loci in a chro­ mosomal region, termed the NK gene complex (NKC), on distal mouse • The US government has the right to retain a nonexclusive, royalty-free license in and to any copyright covering this paper. YOKOYAMA & SEAMAN chromosome 6. Target cell susceptibility to natural killing may be depen­ dent upon specific ligand-receptor interaction with these activating or inhibitory NKC-encoded molecules. INTRODUCTION Natural killer (NK) cells constitute a small population of lymphocytes that typically d isplay a large, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Immunology Annual Reviews

The Ly-49 and NKR-P1 Gene Families Encoding Lectin-Like Receptors on Natural Killer Cells: The NK Gene Complex

Yokoyama, W M; Seaman, W E
Annual Review of Immunology , Volume 11 (1) – Apr 1, 1993
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Publisher
Annual Reviews
Copyright
Copyright 1993 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0732-0582
eISSN
1545-3278
DOI
10.1146/annurev.iy.11.040193.003145
pmid
8476574
Publisher site
See Article on Publisher Site

Abstract

Natural killer cells lyse tumor and virally infected cells in a specific manner that has not been molecularly characterized. Target cell expression of major histocompatibility complex (MHC) class I molecules is correlated with target cell resistance to natural killing. A mechanism to explain this observation is that NK cells may display two types of recognition and activation molecules that have opposing functions when bound to target cell ligands. One type of surface receptor such as the NKR-PI molecule may activate NK activity whereas the other, represented by the mouse Ly--49 molecule, may engage target cell MHC molecules and inhibit cyto­ toxicity by transducing "negative" signals. NKR-Pl and Ly--49 are struc­ turally related, and they are encoded by genetically linked loci in a chro­ mosomal region, termed the NK gene complex (NKC), on distal mouse • The US government has the right to retain a nonexclusive, royalty-free license in and to any copyright covering this paper. YOKOYAMA & SEAMAN chromosome 6. Target cell susceptibility to natural killing may be depen­ dent upon specific ligand-receptor interaction with these activating or inhibitory NKC-encoded molecules. INTRODUCTION Natural killer (NK) cells constitute a small population of lymphocytes that typically d isplay a large,

Journal

Annual Review of Immunology – Annual Reviews

Published: Apr 1, 1993

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