Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

The Major Histocompatibility Complex-Restricted Antigen Receptor on T Cells

The Major Histocompatibility Complex-Restricted Antigen Receptor on T Cells It is now widely accepted by immunologists that antigen recognition by most T lymphocytes occurs through the simultaneous recognition of antigen and a self molecule coded for by genes of the Major Histocompatibility Complex (MHC) , T his fact has considerably complicated our understanding of antigen recognition by T cells, a situation obvious in the literature of the last decade on the T-cell receptor for antigen. Much effort has gone into characterization of the T-cell receptor based on its presumed similarity to immunoglobulin, the antigen receptor on B lymphocytes. In general, studies have focused on the characterization of antibody-like factors, isolated from T cells, that are involved in antigen recognition and that apparently bind antigen in the absence ofMHC products. Described in many reports, these T-cell products have peen desig­ nated as helper or suppressor factors, react with antiimmunoglobulin antisera, and in some cases have been shown to be 70,000 mol wt proteins with or without disulfide-bonded subunits. T hese studies have been summarized in recent reviews (1-11) and are not discussed here. Suffice it to say that the relationship between these factors and the receptors on T cells that recognize antigen in association with MHC products is http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Immunology Annual Reviews

The Major Histocompatibility Complex-Restricted Antigen Receptor on T Cells

Haskins, K; Kappler, J; Marrack, P
Annual Review of Immunology , Volume 2 (1) – Apr 1, 1984
Download PDF
16 pages

Loading next page...
 
/lp/annual-reviews/the-major-histocompatibility-complex-restricted-antigen-receptor-on-t-7CvdXyWReQ
Publisher
Annual Reviews
Copyright
Copyright 1984 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0732-0582
eISSN
1545-3278
DOI
10.1146/annurev.iy.02.040184.000411
pmid
6085752
Publisher site
See Article on Publisher Site

Abstract

It is now widely accepted by immunologists that antigen recognition by most T lymphocytes occurs through the simultaneous recognition of antigen and a self molecule coded for by genes of the Major Histocompatibility Complex (MHC) , T his fact has considerably complicated our understanding of antigen recognition by T cells, a situation obvious in the literature of the last decade on the T-cell receptor for antigen. Much effort has gone into characterization of the T-cell receptor based on its presumed similarity to immunoglobulin, the antigen receptor on B lymphocytes. In general, studies have focused on the characterization of antibody-like factors, isolated from T cells, that are involved in antigen recognition and that apparently bind antigen in the absence ofMHC products. Described in many reports, these T-cell products have peen desig­ nated as helper or suppressor factors, react with antiimmunoglobulin antisera, and in some cases have been shown to be 70,000 mol wt proteins with or without disulfide-bonded subunits. T hese studies have been summarized in recent reviews (1-11) and are not discussed here. Suffice it to say that the relationship between these factors and the receptors on T cells that recognize antigen in association with MHC products is

Journal

Annual Review of Immunology – Annual Reviews

Published: Apr 1, 1984

There are no references for this article.