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The Mode of Action of Chemotherapeutic Agents

The Mode of Action of Chemotherapeutic Agents By ROLLIN D. HOTCHKISS The Rocke feller Institute for Medical Research, New York, N. Y. For the purposes of the present review, chemotherapeutic agents are considered to include all defined preparations which have a pronounced effect upon the viability, or biological proper­ ties, of microorganisms, irrespective of whether or riot these agents have achieved a recognized practical place in therapy. Naturally, sulfonamides, penicillin, and streptomycin dominate this field. However, antiseptics, toxins, and antibacterial agents of various sorts will be dealt with in this review, to the extent to which some­ thing can be said about the nature of their interaction with proto­ plasm. Mere observation of antimicrobial action, e.g., bacterio­ stasis, or bactericidal effect, is not necessarily recorded here, even when these data are available for an elaborate series of chemical modifications of the agent. The period covered is principally from January, 1947 to March, 1948. Work of the preceding year or two which has interest in con­ nection with current studies is sometimes referred to by the authors' names ; a bibliographic reference is not generally given if the earlier work is referred to in the current publications. Subjects not completely covered in this review are: agents http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Microbiology Annual Reviews

The Mode of Action of Chemotherapeutic Agents

Hotchkiss, R D
Annual Review of Microbiology , Volume 2 (1) – Oct 1, 1948
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Publisher
Annual Reviews
Copyright
Copyright 1948 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0066-4227
eISSN
1545-3251
DOI
10.1146/annurev.mi.02.100148.001151
pmid
18122248
Publisher site
See Article on Publisher Site

Abstract

By ROLLIN D. HOTCHKISS The Rocke feller Institute for Medical Research, New York, N. Y. For the purposes of the present review, chemotherapeutic agents are considered to include all defined preparations which have a pronounced effect upon the viability, or biological proper­ ties, of microorganisms, irrespective of whether or riot these agents have achieved a recognized practical place in therapy. Naturally, sulfonamides, penicillin, and streptomycin dominate this field. However, antiseptics, toxins, and antibacterial agents of various sorts will be dealt with in this review, to the extent to which some­ thing can be said about the nature of their interaction with proto­ plasm. Mere observation of antimicrobial action, e.g., bacterio­ stasis, or bactericidal effect, is not necessarily recorded here, even when these data are available for an elaborate series of chemical modifications of the agent. The period covered is principally from January, 1947 to March, 1948. Work of the preceding year or two which has interest in con­ nection with current studies is sometimes referred to by the authors' names ; a bibliographic reference is not generally given if the earlier work is referred to in the current publications. Subjects not completely covered in this review are: agents

Journal

Annual Review of Microbiology – Annual Reviews

Published: Oct 1, 1948

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