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The last ten years have seen an explosive growth in our understanding of IFNI" The cloning of the cDNAs for IFNI' and its receptor have made available large amounts of highly purified recombinant IFNI' and soluble IFNI' receptor. In addition, highly specific neutralizing monoclonal antiÂ bodies have been generated to both of these proteins. Using these reagents, IFNI' and the IFNI' receptor have been characterized on a molecular basis. Structure-function studies carried out on these proteins have identified key molecular regions that are required for biologic activity. Moreover, a great deal is now known concerning the physiologic role that IFNy plays in vivo. In this review we focus on the new developments in the areas of IFNy biochemistry and biology and pay particular attention to the IFNI' receptor and three aspects of IFNI' biology that are of special interest to immunÂ ologists: host defense, inflammation, and autoimmunity. INTRODUCTION Interferon-gamma (IFNI') was first recognized nearly 30 years ago on the basis of its antiviral activity ( 1 ) . During the ensuing years, a great deal of information has accumulated which unequivocally establishes that this pleotropic cytokine plays an important role in modulating nearly all phases of immune and
Annual Review of Immunology – Annual Reviews
Published: Apr 1, 1993
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