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The Molecular Genetics of the T-Cell Antigen Receptor and T-Cell Antigen Recognition

The Molecular Genetics of the T-Cell Antigen Receptor and T-Cell Antigen Recognition T and B lymphocytes participate in the vertebrate immune response through their recognition and elimination of foreign pathogens and macromolecules. Lymphocytes possess both the specificity and the ability to react with a broad range of structures ; these properties are mediated through both T-cell antigen receptors and immunoglobulins that serve as antigen receptors for B cells. Despite some similarities, T-cell antigen recognition and function are different in several important respects from the corresponding processes in B cells. First, T cells recognize only antigens that are present on the surfaces of other cells in the context of polymorphic cell-surface molecules encoded by the major histocompatibility complex (MHC) (1-3). The mechanism by which T-cell receptors express an apparently dual specificity for both antigen and polymorphic determinants of the MHC-encoded molecule is not known and has been the subject of much debate. Second, T cells can be subdivided into separate functional categories including cytotoxic effector cells (Td (4), inducer or helper cells (TH) (5, 6), and suppressor cells (Ts) (7). Since immunoglobulins encode both antigen recognition and effector functions within the same molecule, an important question is whether antigen receptors expressed by different T-cell functional classes are distinct. Third, T cells http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Immunology Annual Reviews

The Molecular Genetics of the T-Cell Antigen Receptor and T-Cell Antigen Recognition

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Publisher
Annual Reviews
Copyright
Copyright 1986 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0732-0582
eISSN
1545-3278
DOI
10.1146/annurev.iy.04.040186.002525
pmid
3518750
Publisher site
See Article on Publisher Site

Abstract

T and B lymphocytes participate in the vertebrate immune response through their recognition and elimination of foreign pathogens and macromolecules. Lymphocytes possess both the specificity and the ability to react with a broad range of structures ; these properties are mediated through both T-cell antigen receptors and immunoglobulins that serve as antigen receptors for B cells. Despite some similarities, T-cell antigen recognition and function are different in several important respects from the corresponding processes in B cells. First, T cells recognize only antigens that are present on the surfaces of other cells in the context of polymorphic cell-surface molecules encoded by the major histocompatibility complex (MHC) (1-3). The mechanism by which T-cell receptors express an apparently dual specificity for both antigen and polymorphic determinants of the MHC-encoded molecule is not known and has been the subject of much debate. Second, T cells can be subdivided into separate functional categories including cytotoxic effector cells (Td (4), inducer or helper cells (TH) (5, 6), and suppressor cells (Ts) (7). Since immunoglobulins encode both antigen recognition and effector functions within the same molecule, an important question is whether antigen receptors expressed by different T-cell functional classes are distinct. Third, T cells

Journal

Annual Review of Immunology – Annual Reviews

Published: Apr 1, 1986

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