Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

The Nature of Antibodies

The Nature of Antibodies By DAN H. CAMPBELL! The Gates and Crellin Laboratories o Chemistry, Cali f fornia Institute o Technology, Pasadena, Cali f fornia2 As more precise physical tools and methods are developed and applied to the chemistry of proteins, the biological as well as physi­ cal nature of antibodies become clearer and our concepts less con­ troversial. Some of these concepts are now based on such sub­ stantial evidence that they must be accepted while others repre­ sent varying but logical interpretations of indirect evidence. This review gives briefly the general immunochemical properties of antibodies and the attendant current interpretations as to their physical and biological significance. A more detailed discussion of antibodies in the recent literature will be found in Boyd's book (1) and a review chapter by Campbell & Lanni (2). PHYSICAL PROPERTIES Chemical composition.-Very little study has been made of the chemical composition of antibody protein, due primarily to the lack of precise chemical analytical methods and sufficient quantities of purified antibody proteins. Smith, Green & Bartner (3) recently studied the amino acid and carbohydrates composition of plasma and colostrum globulins of cattle, as well as plasma globulins of humans and horses. Although they found some slight http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Microbiology Annual Reviews

The Nature of Antibodies

Campbell, D H
Annual Review of Microbiology , Volume 2 (1) – Oct 1, 1948
Download PDF
10 pages

Loading next page...
 
/lp/annual-reviews/the-nature-of-antibodies-le9DjAxI9H
Publisher
Annual Reviews
Copyright
Copyright 1948 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0066-4227
eISSN
1545-3251
DOI
10.1146/annurev.mi.02.100148.001413
pmid
18122249
Publisher site
See Article on Publisher Site

Abstract

By DAN H. CAMPBELL! The Gates and Crellin Laboratories o Chemistry, Cali f fornia Institute o Technology, Pasadena, Cali f fornia2 As more precise physical tools and methods are developed and applied to the chemistry of proteins, the biological as well as physi­ cal nature of antibodies become clearer and our concepts less con­ troversial. Some of these concepts are now based on such sub­ stantial evidence that they must be accepted while others repre­ sent varying but logical interpretations of indirect evidence. This review gives briefly the general immunochemical properties of antibodies and the attendant current interpretations as to their physical and biological significance. A more detailed discussion of antibodies in the recent literature will be found in Boyd's book (1) and a review chapter by Campbell & Lanni (2). PHYSICAL PROPERTIES Chemical composition.-Very little study has been made of the chemical composition of antibody protein, due primarily to the lack of precise chemical analytical methods and sufficient quantities of purified antibody proteins. Smith, Green & Bartner (3) recently studied the amino acid and carbohydrates composition of plasma and colostrum globulins of cattle, as well as plasma globulins of humans and horses. Although they found some slight

Journal

Annual Review of Microbiology – Annual Reviews

Published: Oct 1, 1948

There are no references for this article.