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The Panspecific Hemopoietin of Activated T Lymphocytes (Interleukin-3)

The Panspecific Hemopoietin of Activated T Lymphocytes (Interleukin-3) The T-cell lymphokine that forms the subject of this review has been studied using a variety of bioassays, under many different names. As the discussion below indicates it is now apparent that burst-promoting activity, CFUs­ stimulating activity, histamine-producing cell stimulating factor, inter­ leukin-3, mast-cell growth factor, multicolony-stimulating factor, P cell­ stimulating factor, and WEHI-3 factor are all products of a single gene. The diversity of these assay systems reflects the fact that this single lymphokine stimulates hemopoietic cells from every major hemopoietic lineage. Although there is some controversy, no well-substantiated evi­ dence indicates that this lymphokine acts on lymphoid cells. Because this lymphokine clearly functions as a hemopoietin with a characteristically broad range of targets, where a general term is required the factor will be described as panspecific hemopoietin (PSH). HISTORY In 1963, the first report of the growth in vitro of cells of hemopoietic origin documented the generation of mast cells from cultures of thymic cells (1). Because the cells used in these experiments were taken from noninbred mice, the generation of these mast cells very likely depended on the release of PSH from T cells activated by allogeneic interactions. The myelomonocytic leukemia WEHI-3B that has played http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Immunology Annual Reviews

The Panspecific Hemopoietin of Activated T Lymphocytes (Interleukin-3)

Schrader, J W
Annual Review of Immunology , Volume 4 (1) – Apr 1, 1986
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Publisher
Annual Reviews
Copyright
Copyright 1986 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0732-0582
eISSN
1545-3278
DOI
10.1146/annurev.iy.04.040186.001225
pmid
2871846
Publisher site
See Article on Publisher Site

Abstract

The T-cell lymphokine that forms the subject of this review has been studied using a variety of bioassays, under many different names. As the discussion below indicates it is now apparent that burst-promoting activity, CFUs­ stimulating activity, histamine-producing cell stimulating factor, inter­ leukin-3, mast-cell growth factor, multicolony-stimulating factor, P cell­ stimulating factor, and WEHI-3 factor are all products of a single gene. The diversity of these assay systems reflects the fact that this single lymphokine stimulates hemopoietic cells from every major hemopoietic lineage. Although there is some controversy, no well-substantiated evi­ dence indicates that this lymphokine acts on lymphoid cells. Because this lymphokine clearly functions as a hemopoietin with a characteristically broad range of targets, where a general term is required the factor will be described as panspecific hemopoietin (PSH). HISTORY In 1963, the first report of the growth in vitro of cells of hemopoietic origin documented the generation of mast cells from cultures of thymic cells (1). Because the cells used in these experiments were taken from noninbred mice, the generation of these mast cells very likely depended on the release of PSH from T cells activated by allogeneic interactions. The myelomonocytic leukemia WEHI-3B that has played

Journal

Annual Review of Immunology – Annual Reviews

Published: Apr 1, 1986

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