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The Regulation and Expression of c-myc in Normal and Malignant Cells

The Regulation and Expression of c-myc in Normal and Malignant Cells Lymphocytes exist in a dynamic state that alternates between small quiescent cells and large, antigen-activated, proliferating cells. Their failure to activate properly or to turn off a proliferative program is a likely step in the development of lymphoid malignancies. Understanding the genetic mechanisms that regulate the expression of the alternately quiescent and activated phenotypes is a fundamental question for immunology and oncology. Significant progress in the identification of DNA elements that appear to play a role in the regulation of proliferation and differentiation has come about as a consequence of the isolation of oncogenes, pieces of genetic information that are involved in the malignant transformation of cells. Oncogenes were first isolated as part of the small genomes of rare RNA tumor viruses, called acute transforming retroviruses. These viruses effi­ ciently transform cells in culture and in animals. Acute retroviruses are The US Government has the right to retain a nonexclusive, royalty-free license in and to any copyright covering this paper. KELLY & SIEBENLIST distinct from slow transforming retroviruses that, by contrast, do not possess oncogenes. Accordingly, slow viruses are common in nature, do not transform cells in culture, and only rarely cause tumors in vivo. Normal vertebrate cells http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Immunology Annual Reviews

The Regulation and Expression of c-myc in Normal and Malignant Cells

Kelly, K; Siebenlist, U
Annual Review of Immunology , Volume 4 (1) – Apr 1, 1986
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References (71)

Publisher
Annual Reviews
Copyright
Copyright 1986 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0732-0582
eISSN
1545-3278
DOI
10.1146/annurev.iy.04.040186.001533
pmid
3518746
Publisher site
See Article on Publisher Site

Abstract

Lymphocytes exist in a dynamic state that alternates between small quiescent cells and large, antigen-activated, proliferating cells. Their failure to activate properly or to turn off a proliferative program is a likely step in the development of lymphoid malignancies. Understanding the genetic mechanisms that regulate the expression of the alternately quiescent and activated phenotypes is a fundamental question for immunology and oncology. Significant progress in the identification of DNA elements that appear to play a role in the regulation of proliferation and differentiation has come about as a consequence of the isolation of oncogenes, pieces of genetic information that are involved in the malignant transformation of cells. Oncogenes were first isolated as part of the small genomes of rare RNA tumor viruses, called acute transforming retroviruses. These viruses effi­ ciently transform cells in culture and in animals. Acute retroviruses are The US Government has the right to retain a nonexclusive, royalty-free license in and to any copyright covering this paper. KELLY & SIEBENLIST distinct from slow transforming retroviruses that, by contrast, do not possess oncogenes. Accordingly, slow viruses are common in nature, do not transform cells in culture, and only rarely cause tumors in vivo. Normal vertebrate cells

Journal

Annual Review of Immunology – Annual Reviews

Published: Apr 1, 1986

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