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A. Williams, J. Gagnon (1982)Neuronal cell Thy-1 glycoprotein: homology with immunoglobulin.
Science, 216 4547
C. Chang, M. Short, F. Westholm, F. Stevens, B. Wang, W. Furey, A. Solomon, M. Schiffer (1985)Novel arrangement of immunoglobulin variable domains: X-ray crystallographic analysis of the lambda-chain dimer Bence-Jones protein Loc.
Biochemistry, 24 18
W. Jencks (1969)Catalysis in chemistry and enzymology
J. Berzofsky (1985)Intrinsic and extrinsic factors in protein antigenic structure.
Science, 229 4717
G. Boulot, C. Rojas, G. Bentley, R. Poljak, E. Barbier, C. Guern, P. Cazenave (1987)Preliminary crystallographic study of a complex between the Fab fragment of a monoclonal anti-lysozyme antibody (D1.3) and the Fab fragment from an anti-idiotopic antibody against D1.3.
Journal of molecular biology, 194 3
K. Ely, P. Colman, E. Abola, A. Hess, D. Peabody, D. Parr, G. Connell, C. Laschinger, A. Edmundson (1978)Mobile Fc region in the Zie IgG2 cryoglobulin: comparison of crystals of the F(ab')2 fragment and the intact immunoglobulin.
Biochemistry, 17 5
M. Matsushima, M. Marquart, T. Jones, P. Colman, K. Bartels, R. Huber (1978)Crystal structure of the human Fab fragment Kol and its comparison with the intact Kol molecule.
Journal of molecular biology, 121 4
R. Jemmerson, Y. Paterson (1986)Mapping epitopes on a protein antigen by the proteolysis of antigen-antibody complexes.
Science, 232 4753
R. Arnon, E. Maron, M. Sela, C. Anfinsen (1971)Antibodies reactive with native lysozyme elicited by a completely synthetic antigen.
Proceedings of the National Academy of Sciences of the United States of America, 68 7
L. Amzel, R. Poljak (1979)Three-dimensional structure of immunoglobulins.
Annual review of biochemistry, 48
K. Roux, D. Metzger (1982)Immunoelectron microscopic localization of idiotypes and allotypes on immunoglobulin molecules.
Journal of immunology, 129 6
C. Chothia, J. Janin (1975)Principles of protein–protein recognition
J. Davie, M. Seiden, N. Greenspan, C. Lutz, T. Bartholow, B. Clevinger (1986)Structural correlates of idiotopes.
Annual review of immunology, 4
K. Mostov, M. Friedlander, G. Blobel (1984)The receptor for transepithelial transport of IgA and IgM contains multiple immunoglobulin-like domains
C. Blake, D. Koenig, G. Mair, A. North, D. Phillips, V. Sarma (1965)Structure of Hen Egg-White Lysozyme: A Three-dimensional Fourier Synthesis at 2 Å Resolution
M. Schiffer, R. Girling, K. Ely, A. Edmundson (1972)Structure of a lambda-type Bence-Jones protein at 3.5-A resolution.
Biochemistry, 12 23
R. Hill, R. Delaney, R. Fellows, H. Lebovitz (1966)THE EVOLUTIONARY ORIGINS OF THE IMMUNOGLOBULINS*
Proceedings of the National Academy of Sciences of the United States of America, 56
S. Fraga (1982)Theoretical prediction of protein antigenic determinants from amino acid sequences
Canadian Journal of Chemistry, 60
A. Amit, R. Mariuzza, P. Saludjian, R. Poljak, E. Lamoyi, A. Nisonoff (1983)Preliminary crystallographic study of the Fab fragment of a monoclonal anti-phenylarsonate antibody possessing a major idiotypic specificity.
Journal of molecular biology, 169 2
Jiří Novotný, M. Handschumacher, Edgar Haber (1986)Location of antigenic epitopes on antibody molecules.
Journal of molecular biology, 189 4
F. Menger, M. Ladika (1987)Origin of rate accelerations in an enzyme model: the p-nitrophenyl ester syndrome
Journal of the American Chemical Society, 109
A. Amit, Matthew Harper, R. Mariuzza, P. Saludjian, R. Poljak, E. Lamoyi, A. Nisonoff (1983)Preliminary crystallographic study of the Fab fragment of a monoclonal anti-phenylarsonate antibody.
Journal of molecular biology, 165 2
D. Benjamin, J. Berzofsky, I. East, F. Gurd, C. Hannum, S. Leach, E. Margoliash, J. Michael, A. Miller, E. Prager, M. Reichlin, E. Sercarz, S. Smith‐Gill, P. Todd, A. Wilson (1984)The antigenic structure of proteins: a reappraisal.
Annual review of immunology, 2
T. Hopp, K. Woods (1981)Prediction of protein antigenic determinants from amino acid sequences.
Proceedings of the National Academy of Sciences of the United States of America, 78 6
C.‐H. Chang, W. Carperos, C. Ainsworth, K. Olsent, M. Schiffer (1987)Pronounced effect of the solvent of crystallization on the structure of a multi-domain protein
Acta Crystallographica Section A, 43
M. Atassi (1978)Precise determination of the entire antigenic structure of lysozyme: molecular features of protein antigenic structures and potential of "surface-simulation" synthesis--a powerful new concept for protein binding sites.
Immunochemistry, 15 12
L. Amzel, R. Poljak, F. Saul, J. Varga, F. Richards (1974)The three dimensional structure of a combining region-ligand complex of immunoglobulin NEW at 3.5-A resolution.
Proceedings of the National Academy of Sciences of the United States of America, 71 4
S. Smith‐Gill, A. Wilson, M. Potter, E. Prager, R. Feldmann, C. Mainhart (1982)Mapping the antigenic epitope for a monoclonal antibody against lysozyme.
Journal of immunology, 128 1
L. Gregory, K. Davis, B. Sheth, J. Boyd, R. Jefferis, C. Nave, D. Burton (1987)The solution conformations of the subclasses of human IgG deduced from sedimentation and small angle X-ray scattering studies.
Molecular immunology, 24 8
Y. Satow, G. Cohen, E. Padlan, David Davies (1985)Phosphocholine binding immunoglobulin Fab McPC603. An X-ray diffraction study at 2.7 A.
Journal of molecular biology, 190 4
D. Isenman, K. Dorrington, R. Painter (1975)The structure and function of immunoglobulin domains. II. The importance of interchain disulfide bonds and the possible role of molecular flexibility in the interaction between immunoglobulin G and complement.
Journal of immunology, 114 6
N. Wrigley, E. Brown, J. Skehel (1983)Electron microscopic evidence for the axial rotation and inter-domain flexibility of the Fab regions of immunoglobulin G.
Journal of molecular biology, 169 3
S. Pollack, J. Jacobs, P. Schultz (1986)Selective chemical catalysis by an antibody.
Science, 234 4783
L. Hood, J. Campbell, S. Elgin (1975)The organization, expression, and evolution of antibody genes and other multigene families.
Annual review of genetics, 9
J. Tainer, E. Getzoff, Y. Paterson, A. Olson, R. Lerner (1985)The atomic mobility component of protein antigenicity.
Annual review of immunology, 3
David Fanning, John Smith, G. Rose (1986)Molecular cartography of globular proteins with application to antigenic sites
R. Mariuzza, A. Amit, G. Boulot, P. Saludjian, F. Saul, P. Tougard, R. Poljak, J. Conger, E. Lamoyi, A. Nisonoff (1984)Crystallization of the fab fragments of monoclonal anti-p-azophenylarsonate antibodies and their complexes with haptens.
The Journal of biological chemistry, 259 9
Peter Jones, P. Dear, J. Foote, M. Neuberger, G. Winter (1986)Replacing the complementarity-determining regions in a human antibody with those from a mouse
Roy MariuzzaSg, Ginette BoulotS, Veronique GuillonS, Roberto PoljakS, C. Berekll, J. Jarvisll, Cbar Milsteinn (1985)Preliminary crystallographic study of the Fab fragments of two monoclonal anti-2-phenyloxazolone antibodies.
The Journal of biological chemistry, 260 18
J. Stanford, T. Wu (1981)A predictive method for determining possible three-dimensional foldings of immunoglobulin backbones around antibody combining sites.
Journal of theoretical biology, 88 3
R. Mariuzza, R. Poljak, C. Mihaesco, E. Mihaesco (1983)Crystals of the human heavy chain disease protein Riv and human Fc fragment are isomorphous: further evidence for conformational flexibility in the hinge region of immunoglobulins.
Journal of molecular biology, 165 3
C. Chothia, A. Lesk (1986)The relation between the divergence of sequence and structure in proteins.
The EMBO Journal, 5
A. Miller, L. Ch'ng, CHRISTOPHER Benjamin, E. Sercarz, P. Brodeur, R. Riblet (1983)Detailed Analysis of the Public Idiotype of Anti‐Hen Egg‐White Lysozyme Antibodies a
Annals of the New York Academy of Sciences, 418
G. Köhler, C. Milstein (1975)Continuous cultures of fused cells secreting antibody of predefined specificity
Sally Roberts, Janet Cheetham, Anthony Rees (1987)Generation of an antibody with enhanced affinity and specificity for its antigen by protein engineering
J. Thornton, M. Edwards, W. Taylor, D. Barlow (1986)Location of ‘continuous’ antigenic determinants in the protruding regions of proteins.
The EMBO Journal, 5
E. Padlan (1985)Quantitation of the immunogenic potential of protein antigens.
Molecular immunology, 22 11
S. Smith‐Gill, C. Mainhart, T. Lavoie, S. Rudikoff, M. Potter (1984)VL-VH expression by monoclonal antibodies recognizing avian lysozyme.
Journal of immunology, 132 2
R. Mariuzza, D. Janković, G. Boulot, A. Amit, P. Saludjian, A.-S. Guern, J. Mazié, R. Poljak (1983)Preliminary crystallographic study of the complex between the Fab fragment of a monoclonal anti-lysozyme antibody and its antigen.
Journal of molecular biology, 170 4
D. Segal, E. Padlan, G. Cohen, S. Rudikoff, M. Potter, D. Davies (1974)The three-dimensional structure of a phosphorylcholine-binding mouse immunoglobulin Fab and the nature of the antigen binding site.
Proceedings of the National Academy of Sciences of the United States of America, 71 11
E. Kabat, T. Wu (1971)ATTEMPTS TO LOCATE COMPLEMENTARITY‐DETERMINING RESIDUES IN THE VARIABLE POSITIONS OF LIGHT AND HEAVY CHAINS *
Annals of the New York Academy of Sciences, 190
Peter Colman, W. Laver, Joseph Varghese, A. Baker, P. Tulloch, G. Air, R. Webster (1987)Three-dimensional structure of a complex of antibody with influenza virus neuraminidase
D. Davies, H. Metzger (1983)Structural basis of antibody function.
Annual review of immunology, 1
A. Amit, R. Mariuzza, Simon Phillips, R. Poljak (1985)Three-dimensional structure of an antigen–antibody complex at 6 Å resolution
Fortune Kohen, J. Kim, Hans Lindner, Zelig Eshhar, B. Green (1980)Monoclonal immunoglobulin G augments hydrolysis of an ester of the homologous hapten
FEBS Letters, 111
E. Mozes, E. Maron, R. Arnon, M. Sela (1971)[Strain-dependent differences in the specificity of antibody responses toward lysozyme].
Journal of immunology, 106 3
J. Tainer, E. Getzoff, H. Alexander, R. Houghten, A. Olson, R. Lerner, W. Hendrickson (1984)The reactivity of anti-peptide antibodies is a function of the atomic mobility of sites in a protein
M. Cygler, A. Boodhoo, Jeremy Lee, W. Anderson (1987)Crystallization and structure determination of an autoimmune anti-poly(dT) immunoglobulin Fab fragment at 3.0 A resolution.
The Journal of biological chemistry, 262 2
S. Tonegawa (1983)Somatic generation of antibody diversity
P. Travers, T. Blundell, Michael Sternberg, Walter Bodmer (1984)Structural and evolutionary analysis of HLA-D-region products
I. Ibrahimi, J. Eder, E. Prager, A. Wilson, R. Arnon (1980)The effect of a single amino acid substitution on the antigenic specificity of the loop region of lysozyme.
Molecular immunology, 17 1
O. Epp, P. Colman, H. Fehlhammer, W. Bode, R. Huber, M. Schiffer, W. Palm (1974)Crystal and molecular structure of a dimer composed of the variable portions of the Bence-Jones protein REI.
European journal of biochemistry, 45 2
R. Poljak, L. Amzel, H. Avey, Bo Chen, R. Phizackerley, F. Saul (1973)Three-dimensional structure of the Fab' fragment of a human immunoglobulin at 2,8-A resolution.
Proceedings of the National Academy of Sciences of the United States of America, 70 12
Debora Foster, K. Dorrington, R. Painter (1978)Structure and function of immunoglobulin domains. VII. Studies on the structural requirements of human immunoglobulin G for granulocyte binding.
Journal of immunology, 120 6
E. Westhof, D. Altschuh, D. Moras, A. Bloomer, A. Mondragón, A. Klug, M. Regenmortel (1984)Correlation between segmental mobility and the location of antigenic determinants in proteins
M. Neuberger (1983)Expression and regulation of immunoglobulin heavy chain gene transfected into lymphoid cells.
The EMBO Journal, 2
Z. Moudallal, J. Briand, M. Regenmortel (1985)A major part of the polypeptide chain of tobacco mosaic virus protein is antigenic
The EMBO Journal, 4
The general principles of the genetic control and the three-dimensional structure of antibody molecules have been worked out in the last 20 years. This very exciting period has seen the unraveling of the mechanisms that generate diversity in a molecule which participates in an adaptive response to varied environmental conditions. This diversity is superimposed on a pattern of genetic transmission of constant hereditary traits and, in molecÂ ular terms, a constant molecular structure. The antibody molecule has thus been repeatedly presented as a paradigm of biological flexibility; its functional and structural individuality is superimposed on a carefully conserved structure. However, not all the problems posed by antibody function and specificity a detailed understanding of the structural bases of specifcity i physicochemical characterization of antibody action at the molecular level are only beginning. Ways of approaching these problems have been cleared by recent developments in the characterization of immune processes and of the cells and molecules that are the effectors of those processes. In addition to that research, there is a continuing search for a molecular definition of immunogenicity and antigenicity, for new uses of antibody molecules in regulating immune responses, in mimicking foreign antigens, and in delivering therapeutic
Annual Review of Immunology – Annual Reviews
Published: Apr 1, 1988
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