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Toxicological Aspects of Alterations of Pulmonary Macrophage Function

Toxicological Aspects of Alterations of Pulmonary Macrophage Function Pulmonary macrophages are similar to mononuclear phagocytes throughout the body, such as those found in the peritoneal cavity or liver. Yet, pulmonary macrophages face unique challenges. Found on the inner surfaces of the respiratory tract, they come in direct contact with toxic particles and gases as well as pathogens contained in the inspired air. Their mobility, phagocytic capacity, and bactericidal properties are essential to the maintenance of clean and sterile alveoli. Since these cells are accessible by bronchopulmonary lavage, they have been studied extensively in vitro. Our knowledge of the cell biology and toxicology of phagocytic cells has been extended by experiments with isolated pulmonary macrophages. These cells are of interest since their migratory patterns, phagocytic behavior, and secretory potential are pivotal events in the pathogenesis of pulmonary disease. Even though macrophages are an essential line of defense for airway and alveolar surfaces, they can also injure the host. For these reasons, the toxicology of pulmonary macrophages is an essential aspect of how toxic agents injure the lung (I). Under certain conditions, macrophages are damaged as a consequence of particle ingestion, and the nature of that damage is relevant to pUlmonary disease. In response to phagocytic stimuli, macrophages http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Pharmacology and Toxicology Annual Reviews

Toxicological Aspects of Alterations of Pulmonary Macrophage Function

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References (29)

Publisher
Annual Reviews
Copyright
Copyright 1986 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0362-1642
eISSN
1545-4304
DOI
10.1146/annurev.pa.26.040186.002555
pmid
3521463
Publisher site
See Article on Publisher Site

Abstract

Pulmonary macrophages are similar to mononuclear phagocytes throughout the body, such as those found in the peritoneal cavity or liver. Yet, pulmonary macrophages face unique challenges. Found on the inner surfaces of the respiratory tract, they come in direct contact with toxic particles and gases as well as pathogens contained in the inspired air. Their mobility, phagocytic capacity, and bactericidal properties are essential to the maintenance of clean and sterile alveoli. Since these cells are accessible by bronchopulmonary lavage, they have been studied extensively in vitro. Our knowledge of the cell biology and toxicology of phagocytic cells has been extended by experiments with isolated pulmonary macrophages. These cells are of interest since their migratory patterns, phagocytic behavior, and secretory potential are pivotal events in the pathogenesis of pulmonary disease. Even though macrophages are an essential line of defense for airway and alveolar surfaces, they can also injure the host. For these reasons, the toxicology of pulmonary macrophages is an essential aspect of how toxic agents injure the lung (I). Under certain conditions, macrophages are damaged as a consequence of particle ingestion, and the nature of that damage is relevant to pUlmonary disease. In response to phagocytic stimuli, macrophages

Journal

Annual Review of Pharmacology and Toxicology – Annual Reviews

Published: Apr 1, 1986

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