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/lp/annual-reviews/transcriptional-control-of-early-t-and-b-cell-developmental-choices-o1ASY1QvMT
- Publisher
- Annual Reviews
- Copyright
- Copyright © 2014 by Annual Reviews. All rights reserved
- ISSN
- 0732-0582
- eISSN
- 1545-3278
- DOI
- 10.1146/annurev-immunol-032712-100024
- pmid
- 24471430
- Publisher site
- See Article on Publisher Site
Abstract
T and B cells share a common somatic gene rearrangement mechanism for assembling the genes that code for their antigen receptors; they also have developmental pathways with many parallels. Shared usage of basic helix-loop-helix E proteins as transcriptional drivers underlies these common features. However, the transcription factor networks in which these E proteins are embedded are different both in membership and in architecture for T and B cell gene regulatory programs. These differences permit lineage commitment decisions to be made in different hierarchical orders. Furthermore, in contrast to B cell gene networks, the T cell gene network architecture for effector differentiation is sufficiently modular so that E protein inputs can be removed. Complete T cell–like effector differentiation can proceed without T cell receptor rearrangement or selection when E proteins are neutralized, yielding natural killer and other innate lymphoid cells.
Journal
Annual Review of Immunology – Annual Reviews
Published: Mar 21, 2014