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TRANSCRIPTIONAL REGULATION DURING B CELL DEVELOPMENT

TRANSCRIPTIONAL REGULATION DURING B CELL DEVELOPMENT ▪ Abstract Information is increasingly available concerning the molecular events that occur during primary and antigen-dependent stages of B cell development. In this review the roles of transcription factors and coactivators are discussed with respect to changes in expression patterns of various genes during B cell development. Transcriptional regulation is also discussed in the context of developmentally regulated immunoglobulin gene V(D)J recombination, somatic hypermutation, and isotype switch recombination. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Immunology Annual Reviews

TRANSCRIPTIONAL REGULATION DURING B CELL DEVELOPMENT

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Publisher
Annual Reviews
Copyright
Copyright © 1998 by Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0732-0582
eISSN
1545-3278
DOI
10.1146/annurev.immunol.16.1.163
pmid
9597128
Publisher site
See Article on Publisher Site

Abstract

▪ Abstract Information is increasingly available concerning the molecular events that occur during primary and antigen-dependent stages of B cell development. In this review the roles of transcription factors and coactivators are discussed with respect to changes in expression patterns of various genes during B cell development. Transcriptional regulation is also discussed in the context of developmentally regulated immunoglobulin gene V(D)J recombination, somatic hypermutation, and isotype switch recombination.

Journal

Annual Review of Immunology – Annual Reviews

Published: Apr 1, 1998

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