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Transcriptional Regulation of T Cell Receptor Genes

Transcriptional Regulation of T Cell Receptor Genes The diverse lineages of the mammalian hematopoietic system including both B and T lymphocytes are derived from a single mesodermal progeni­ tor, the pluripotent bone marrow stem cell. The coordinate transcriptional regulation of sets oflineage-specific genes is one of the important molecular mechanisms underlying hematopoietic lineage determination and differ­ entiation. The immunoglobulin and T cell receptor (TCR) genes have been used as model systems to study lineage-specific transcriptional regulation during lymphoid development. This review summarizes our current under­ standing of the regulation of TCR gene expression during thymocyte ontogeny. Expression of each of the TCR genes is controlled by T cell­ specific transcriptional enhancers that bind partially overlapping sets of ubiquitous and lymphoid-specific transcription factors. These include members of both the A TF(CREB family of basic-leucine zipper proteins and the Ets protooncogene family, as well as the T cell-specific zinc finger transcription factor, GATA-3, and the T cell-specific high mobility group proteins TCF-l and TCF-lct/LEF-l. The identification of binding sites for these same transcription factors in a number of additional T cell­ specific genes suggests that they may play important roles in the coordinate regulation of gene expression that specifies the development of the T cell lineages. Recent http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Immunology Annual Reviews

Transcriptional Regulation of T Cell Receptor Genes

Leiden, J M
Annual Review of Immunology , Volume 11 (1) – Apr 1, 1993
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Publisher
Annual Reviews
Copyright
Copyright 1993 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0732-0582
eISSN
1545-3278
DOI
10.1146/annurev.iy.11.040193.002543
pmid
8476572
Publisher site
See Article on Publisher Site

Abstract

The diverse lineages of the mammalian hematopoietic system including both B and T lymphocytes are derived from a single mesodermal progeni­ tor, the pluripotent bone marrow stem cell. The coordinate transcriptional regulation of sets oflineage-specific genes is one of the important molecular mechanisms underlying hematopoietic lineage determination and differ­ entiation. The immunoglobulin and T cell receptor (TCR) genes have been used as model systems to study lineage-specific transcriptional regulation during lymphoid development. This review summarizes our current under­ standing of the regulation of TCR gene expression during thymocyte ontogeny. Expression of each of the TCR genes is controlled by T cell­ specific transcriptional enhancers that bind partially overlapping sets of ubiquitous and lymphoid-specific transcription factors. These include members of both the A TF(CREB family of basic-leucine zipper proteins and the Ets protooncogene family, as well as the T cell-specific zinc finger transcription factor, GATA-3, and the T cell-specific high mobility group proteins TCF-l and TCF-lct/LEF-l. The identification of binding sites for these same transcription factors in a number of additional T cell­ specific genes suggests that they may play important roles in the coordinate regulation of gene expression that specifies the development of the T cell lineages. Recent

Journal

Annual Review of Immunology – Annual Reviews

Published: Apr 1, 1993

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