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Transgenic Mice and Oncogenesis

Transgenic Mice and Oncogenesis The creation of transgenic mice carrying specific cancer-promoting genes has opened an exciting new era in oncology. The biological effects of an individual oncogene on diverse cell types can now be assessed directly within the living animal. While transgenic animals bear the introduced oncogene in every tissue, expression of that gene may either be widespread or directed to a particular cell lineage, depending upon the regulatory sequences chosen. The transgene should behave identically in every animal of an established lineage and, indeed, perhaps in every cell of a given type. Thus, a well-characterized transgenic line becomes a permanent resource. Perhaps the most significant opportunity provided by these transgenic animals is the possibility of exploring the pre-neoplastic state. One can attempt to assess whether an oncogene has perturbed differentiation within particular lineages. The perturbations may help to delineate early matu­ ration stages and to clarify how differentiation is controlled. Thus, new insights may emerge regarding the normal biological functions of proto­ oncogenes. The rules for oncogene cooperativity can also be evaluated within diverse cell types. For example, one can isolate the relevant cells from a pre-neoplastic animal bearing an oncogene and attempt to trans­ form them fully in vitro http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Immunology Annual Reviews

Transgenic Mice and Oncogenesis

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Publisher
Annual Reviews
Copyright
Copyright 1988 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0732-0582
eISSN
1545-3278
DOI
10.1146/annurev.iy.06.040188.000325
pmid
2838049
Publisher site
See Article on Publisher Site

Abstract

The creation of transgenic mice carrying specific cancer-promoting genes has opened an exciting new era in oncology. The biological effects of an individual oncogene on diverse cell types can now be assessed directly within the living animal. While transgenic animals bear the introduced oncogene in every tissue, expression of that gene may either be widespread or directed to a particular cell lineage, depending upon the regulatory sequences chosen. The transgene should behave identically in every animal of an established lineage and, indeed, perhaps in every cell of a given type. Thus, a well-characterized transgenic line becomes a permanent resource. Perhaps the most significant opportunity provided by these transgenic animals is the possibility of exploring the pre-neoplastic state. One can attempt to assess whether an oncogene has perturbed differentiation within particular lineages. The perturbations may help to delineate early matu­ ration stages and to clarify how differentiation is controlled. Thus, new insights may emerge regarding the normal biological functions of proto­ oncogenes. The rules for oncogene cooperativity can also be evaluated within diverse cell types. For example, one can isolate the relevant cells from a pre-neoplastic animal bearing an oncogene and attempt to trans­ form them fully in vitro

Journal

Annual Review of Immunology – Annual Reviews

Published: Apr 1, 1988

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