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Tumor-Associated Carbohydrate Antigens

Tumor-Associated Carbohydrate Antigens Sen-itiroh Hakomori Program of Biochemical Oncology/Membrane Research, Fred Hutchinson Cancer Research Center; Department of Pathobiology, Microbiology, Immunology, University of Washington, Seattle, Washington 98104 INTRODUC TION Cells oncogenically transformed in vitro, or taken from in vivo tumors, display distinctively different profiles and structures in cell-surface carbohydrates from those of nontransformed progenitor cells. Changes in carbohydrate structure in tumor cells are essentially quantitative rather than qualitative-i. e. a smaller I Abbreviations and nomenclature. Nomenclature of glycolipids follows the recommendations of the Nomenclature Committee, I nternational Union of Pure and Applied Chemistry (125 ) . Cer = ceramide (N-fatty acyl sphingosine); LacCer = = Gall3l�4Glc�Cer; Gg3 = = "asialo GM2", GaINAcl3l�4Gall3l�4Glc�Cer; Gg4 4Glc�Cer; Gb3 = " CTH" "asialo GM1", Gall3l�3GaINAcl3l � 4Gall3l� "globoside", GaINAcl3l� = = 3Gala 1�4GaI131�4G lc�Cer; IV3NeuAcu2->3GalGb4 = Galal�4Gall3l� lc�Cer; Gb4 4G sialosylgalactosylgloboside Forssman NeuAca2�3Gal131 �3GalNAc131 �3Gala I � 4Ga1131�4Glc�Cer; 4Glc� Cer; nLc4 antigen GaINAca l�3GalNAcl3l�3Gala l�4Gall3l->4Glc->Cer; LC3 = GlcNAcf31->3Galf3l-> = Gall3l->4GlcNAcl3l->3Gall3l-> 4Glc�Cer;Lc4 = Gall3l->3GlcNAcl3l� Gall3l->4GlcNAcf3I->3Galf31�4GlcNAcf3I->3Galf31-> 3Gall3l->4Glc�Cer; nLc6 4Glc->Cer; nLcs = Gall3l->4GlcNAcl3l->3GaI131- >4GlcNAcf3I->3GaI131�4GlcNAcf3l� 3Gall3l- >4Glc�Cer; iLcs Galf31 ->4GlcNAcf31�3[Galf31�4GlcNAcf3I->6JGalf3l-> = 4GlcNAcf3I�3Gall3l- >4Glc->Cer; Lea Fuca l->2Gall3l->3[Fuca l->4JGlcNAcf3I->R; X = Gall3l- >3[Fuca l-> 4]GlcNAcf3I->R; Le = b = 4GlcNAcl3l->3Gall3l->4GlcNAcf31->3Galf3I->4Glc->Cer; Z. = Vne FucnLcs Galf3l-> 4lFuca 1->3] GlcNAcf3I->3Galf3l-> 4GlcNAcf31->3Galf31-> 4GlcNAcf31->3Galf31-> 4Glc-> Galf3I->4[Fuca http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Immunology Annual Reviews

Tumor-Associated Carbohydrate Antigens

Hakomori, Sen-itiroh
Annual Review of Immunology , Volume 2 (1) – Apr 1, 1984
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Publisher
Annual Reviews
Copyright
Copyright 1984 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0732-0582
eISSN
1545-3278
DOI
10.1146/annurev.iy.02.040184.000535
pmid
6085749
Publisher site
See Article on Publisher Site

Abstract

Sen-itiroh Hakomori Program of Biochemical Oncology/Membrane Research, Fred Hutchinson Cancer Research Center; Department of Pathobiology, Microbiology, Immunology, University of Washington, Seattle, Washington 98104 INTRODUC TION Cells oncogenically transformed in vitro, or taken from in vivo tumors, display distinctively different profiles and structures in cell-surface carbohydrates from those of nontransformed progenitor cells. Changes in carbohydrate structure in tumor cells are essentially quantitative rather than qualitative-i. e. a smaller I Abbreviations and nomenclature. Nomenclature of glycolipids follows the recommendations of the Nomenclature Committee, I nternational Union of Pure and Applied Chemistry (125 ) . Cer = ceramide (N-fatty acyl sphingosine); LacCer = = Gall3l�4Glc�Cer; Gg3 = = "asialo GM2", GaINAcl3l�4Gall3l�4Glc�Cer; Gg4 4Glc�Cer; Gb3 = " CTH" "asialo GM1", Gall3l�3GaINAcl3l � 4Gall3l� "globoside", GaINAcl3l� = = 3Gala 1�4GaI131�4G lc�Cer; IV3NeuAcu2->3GalGb4 = Galal�4Gall3l� lc�Cer; Gb4 4G sialosylgalactosylgloboside Forssman NeuAca2�3Gal131 �3GalNAc131 �3Gala I � 4Ga1131�4Glc�Cer; 4Glc� Cer; nLc4 antigen GaINAca l�3GalNAcl3l�3Gala l�4Gall3l->4Glc->Cer; LC3 = GlcNAcf31->3Galf3l-> = Gall3l->4GlcNAcl3l->3Gall3l-> 4Glc�Cer;Lc4 = Gall3l->3GlcNAcl3l� Gall3l->4GlcNAcf3I->3Galf31�4GlcNAcf3I->3Galf31-> 3Gall3l->4Glc�Cer; nLc6 4Glc->Cer; nLcs = Gall3l->4GlcNAcl3l->3GaI131- >4GlcNAcf3I->3GaI131�4GlcNAcf3l� 3Gall3l- >4Glc�Cer; iLcs Galf31 ->4GlcNAcf31�3[Galf31�4GlcNAcf3I->6JGalf3l-> = 4GlcNAcf3I�3Gall3l- >4Glc->Cer; Lea Fuca l->2Gall3l->3[Fuca l->4JGlcNAcf3I->R; X = Gall3l- >3[Fuca l-> 4]GlcNAcf3I->R; Le = b = 4GlcNAcl3l->3Gall3l->4GlcNAcf31->3Galf3I->4Glc->Cer; Z. = Vne FucnLcs Galf3l-> 4lFuca 1->3] GlcNAcf3I->3Galf3l-> 4GlcNAcf31->3Galf31-> 4GlcNAcf31->3Galf31-> 4Glc-> Galf3I->4[Fuca

Journal

Annual Review of Immunology – Annual Reviews

Published: Apr 1, 1984

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