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Veto Cells

Veto Cells One of the main problems confronting an immune system designed to eliminate foreign substances is the establishment and maintenance of self­ tolerance. Two schools of thought exist on how self-reactivity in the T cell compartment is avoided. One mechanism, clonal deletion, proposes that self-tolerance is imposed on immature T cells in the thymus-that at a certain stage of differentiation, contact with antigen permanently inac­ tivates the cell (1, 2). An alternative, nonmutually exclusive suggestion is that anti-idiotypic suppressor mechanisms exist to inhibit continually any potential self reactivity. According to this hypothesis, anti-A reactive T cells are held in check by anti-(anti-A) suppressor T cells (3, 4, 5). Most self-tolerance in the population of T cells is apparently imposed by clonal deletion of autoreactive lymphocytes within the thymus. However, this mechanism of avoiding autoimmune recognition may alone be insufficient, as autoreactive T cells can be isolated from the population of mature peripheral lymphocytes, and in fact, syngeneic cytolysis can be demon­ strated in many allospecific cytotoxic T lymphocyte (C TL) clones (6). In the following pages we argue for the presence of a mechanism, other than one involving anti-idiotypic networks, for the continued maintenance of self-tolerance in the pool http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Immunology Annual Reviews

Veto Cells

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Publisher
Annual Reviews
Copyright
Copyright 1988 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0732-0582
eISSN
1545-3278
DOI
10.1146/annurev.iy.06.040188.000555
pmid
2898250
Publisher site
See Article on Publisher Site

Abstract

One of the main problems confronting an immune system designed to eliminate foreign substances is the establishment and maintenance of self­ tolerance. Two schools of thought exist on how self-reactivity in the T cell compartment is avoided. One mechanism, clonal deletion, proposes that self-tolerance is imposed on immature T cells in the thymus-that at a certain stage of differentiation, contact with antigen permanently inac­ tivates the cell (1, 2). An alternative, nonmutually exclusive suggestion is that anti-idiotypic suppressor mechanisms exist to inhibit continually any potential self reactivity. According to this hypothesis, anti-A reactive T cells are held in check by anti-(anti-A) suppressor T cells (3, 4, 5). Most self-tolerance in the population of T cells is apparently imposed by clonal deletion of autoreactive lymphocytes within the thymus. However, this mechanism of avoiding autoimmune recognition may alone be insufficient, as autoreactive T cells can be isolated from the population of mature peripheral lymphocytes, and in fact, syngeneic cytolysis can be demon­ strated in many allospecific cytotoxic T lymphocyte (C TL) clones (6). In the following pages we argue for the presence of a mechanism, other than one involving anti-idiotypic networks, for the continued maintenance of self-tolerance in the pool

Journal

Annual Review of Immunology – Annual Reviews

Published: Apr 1, 1988

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