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Trinucleotide repeats in the human androgen receptor: a molecular basis for disease

Trinucleotide repeats in the human androgen receptor: a molecular basis for disease REVIEW Trinucleotide repeats in the human androgen receptor: a molecular basis for disease 1 2 C S Choong and E M Wilson Department of Pediatric Endocrinology, Mater Misericordiae Children’s Hospital, South Brisbane, Queensland 4101, Australia The Laboratories for Reproductive Biology and the Departments of Pediatrics and Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina 27599–7500, USA (Requests for oVprints should be addressed toEMWilson) THE ANDROGEN RECEPTOR major AR mRNA species is about 10 kilobases (kb) with a less abundant mRNA of 7 kb detected in Sequence similarities among the steroid some human tissues (Lubahn et al. 1988a). receptor family of nuclear receptors DiVerences in the published AR cDNA sequence relate primarily to two polymorphic trinucleotide The androgen receptor (AR) is a member of the repeats encoding polyglutamine and polyglycine superfamily of nuclear hormone receptors (Zhou within the first exon (Chang et al. 1988a, Lubahn et al. 1994). This family of ligand-dependent et al. 1988b, Tilley et al. 1989). Functional transcription factors are key regulatory proteins in organization of AR is similar to that of the other diverse physiological processes, including embryo- members of the steroid receptor family (Lubahn genesis, development and homeostasis. Steroids are et al. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Molecular Endocrinology Bioscientifica

Trinucleotide repeats in the human androgen receptor: a molecular basis for disease

Journal of Molecular Endocrinology , Volume 21 (3) – Dec 1, 1998

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References (206)

Publisher
Bioscientifica
Copyright
Copyright © 1998 The Authors. All Rights Reserved.
ISSN
0952-5041
eISSN
1479-6813
DOI
10.1677/jme.0.0210235
Publisher site
See Article on Publisher Site

Abstract

REVIEW Trinucleotide repeats in the human androgen receptor: a molecular basis for disease 1 2 C S Choong and E M Wilson Department of Pediatric Endocrinology, Mater Misericordiae Children’s Hospital, South Brisbane, Queensland 4101, Australia The Laboratories for Reproductive Biology and the Departments of Pediatrics and Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina 27599–7500, USA (Requests for oVprints should be addressed toEMWilson) THE ANDROGEN RECEPTOR major AR mRNA species is about 10 kilobases (kb) with a less abundant mRNA of 7 kb detected in Sequence similarities among the steroid some human tissues (Lubahn et al. 1988a). receptor family of nuclear receptors DiVerences in the published AR cDNA sequence relate primarily to two polymorphic trinucleotide The androgen receptor (AR) is a member of the repeats encoding polyglutamine and polyglycine superfamily of nuclear hormone receptors (Zhou within the first exon (Chang et al. 1988a, Lubahn et al. 1994). This family of ligand-dependent et al. 1988b, Tilley et al. 1989). Functional transcription factors are key regulatory proteins in organization of AR is similar to that of the other diverse physiological processes, including embryo- members of the steroid receptor family (Lubahn genesis, development and homeostasis. Steroids are et al.

Journal

Journal of Molecular EndocrinologyBioscientifica

Published: Dec 1, 1998

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