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Differences in duration of Huntington’s disease based on age at onset

Differences in duration of Huntington’s disease based on age at onset OBJECTIVES Data from a sample of 2494 patients affected with Huntington’s disease (HD), collected as part of the National Research Roster for Huntington Disease Patients and Families, were examined to determine if there was a relation between age at onset and duration of illness. METHODS Sufficient data for inclusion in analysis was available from 2068 patients, of whom 828 were deceased and 1240 were living. The median duration of disease was 21.4 years with a range of 1.2 to 40.8 years. Patients were categorised into one of four groups based on their age at onset. RESULTS Significant differences in duration based on the age at onset were found (p<0.025), with juvenile and late onset patients with HD having shorter duration of illness compared with those with an onset between 20–49 years. CONCLUSIONS Duration of disease is influenced by the age at symptom onset with juvenile and late onset patients having the shortest duration. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Neurology Neurosurgery & Psychiatry British Medical Journal

Differences in duration of Huntington’s disease based on age at onset

Differences in duration of Huntington’s disease based on age at onset

Journal of Neurology Neurosurgery & Psychiatry , Volume 66 (1) – Jan 1, 1999

Abstract



OBJECTIVES
Data from a sample of 2494 patients affected with Huntington’s disease (HD), collected as part of the National Research Roster for Huntington Disease Patients and Families, were examined to determine if there was a relation between age at onset and duration of illness.


METHODS
Sufficient data for inclusion in analysis was available from 2068 patients, of whom 828 were deceased and 1240 were living. The median duration of disease was 21.4 years with a range of 1.2 to 40.8 years. Patients were categorised into one of four groups based on their age at onset.


RESULTS
Significant differences in duration based on the age at onset were found (p<0.025), with juvenile and late onset patients with HD having shorter duration of illness compared with those with an onset between 20–49 years.


CONCLUSIONS
Duration of disease is influenced by the age at symptom onset with juvenile and late onset patients having the shortest duration.

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Publisher
British Medical Journal
Copyright
Journal of Neurology, Neurosurgery, and Psychiatry
ISSN
0022-3050
eISSN
1468-330X
DOI
10.1136/jnnp.66.1.52
Publisher site
See Article on Publisher Site

Abstract

OBJECTIVES Data from a sample of 2494 patients affected with Huntington’s disease (HD), collected as part of the National Research Roster for Huntington Disease Patients and Families, were examined to determine if there was a relation between age at onset and duration of illness. METHODS Sufficient data for inclusion in analysis was available from 2068 patients, of whom 828 were deceased and 1240 were living. The median duration of disease was 21.4 years with a range of 1.2 to 40.8 years. Patients were categorised into one of four groups based on their age at onset. RESULTS Significant differences in duration based on the age at onset were found (p<0.025), with juvenile and late onset patients with HD having shorter duration of illness compared with those with an onset between 20–49 years. CONCLUSIONS Duration of disease is influenced by the age at symptom onset with juvenile and late onset patients having the shortest duration.

Journal

Journal of Neurology Neurosurgery & PsychiatryBritish Medical Journal

Published: Jan 1, 1999

Keywords: Huntington’s disease duration age at onset

References