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Human Papillomavirus Detection and Genotyping on Pelvic Nodes in Patients With Synchronous Gynecological Malignancies: A Tool for Identifying the Primary Site of Lymphatic Spread?

Human Papillomavirus Detection and Genotyping on Pelvic Nodes in Patients With Synchronous... Introduction:Synchronous gynecological tumors are uncommon. Identifying the primary site of lymphatic spread may be difficult.Methods:Two women with synchronous squamous cervical and adenosquamous endometrial cancers (patient A) and squamous cervical and serous borderline ovarian tumors (patient B) entered retrospectively this study. Both patients had pelvic nodal metastases of unknown origin. Uterine cervix, endometrium, and lymph nodes were tested for human papillomavirus DNA using high-sensitive polymerase chain reaction, followed by oligonucleotide microarray for genotyping.Results:Human papillomavirus 16 DNA was extracted from portio vaginalis and pelvic nodes of both women. Viral homology between cervical and lymph nodal lesions helped to identify the primary metastasizing tumors in both patients.Conclusions:Human papillomavirus testing on pelvic lymphatic tissue represents a feasible tool to detect the primary site of lymphatic spread in synchronous gynecological malignancies, when uterine cervix is involved. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png International Journal of Gynecological Cancer British Medical Journal

Human Papillomavirus Detection and Genotyping on Pelvic Nodes in Patients With Synchronous Gynecological Malignancies: A Tool for Identifying the Primary Site of Lymphatic Spread?

Human Papillomavirus Detection and Genotyping on Pelvic Nodes in Patients With Synchronous Gynecological Malignancies: A Tool for Identifying the Primary Site of Lymphatic Spread?

International Journal of Gynecological Cancer , Volume 20 (8) – Oct 1, 2010

Abstract

Introduction:Synchronous gynecological tumors are uncommon. Identifying the primary site of lymphatic spread may be difficult.Methods:Two women with synchronous squamous cervical and adenosquamous endometrial cancers (patient A) and squamous cervical and serous borderline ovarian tumors (patient B) entered retrospectively this study. Both patients had pelvic nodal metastases of unknown origin. Uterine cervix, endometrium, and lymph nodes were tested for human papillomavirus DNA using high-sensitive polymerase chain reaction, followed by oligonucleotide microarray for genotyping.Results:Human papillomavirus 16 DNA was extracted from portio vaginalis and pelvic nodes of both women. Viral homology between cervical and lymph nodal lesions helped to identify the primary metastasizing tumors in both patients.Conclusions:Human papillomavirus testing on pelvic lymphatic tissue represents a feasible tool to detect the primary site of lymphatic spread in synchronous gynecological malignancies, when uterine cervix is involved.

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Publisher
British Medical Journal
Copyright
Copyright © 2010 by IGCS and ESGO
ISSN
1048-891X
eISSN
1525-1438
DOI
10.1111/IGC.0b013e3181f294f0
Publisher site
See Article on Publisher Site

Abstract

Introduction:Synchronous gynecological tumors are uncommon. Identifying the primary site of lymphatic spread may be difficult.Methods:Two women with synchronous squamous cervical and adenosquamous endometrial cancers (patient A) and squamous cervical and serous borderline ovarian tumors (patient B) entered retrospectively this study. Both patients had pelvic nodal metastases of unknown origin. Uterine cervix, endometrium, and lymph nodes were tested for human papillomavirus DNA using high-sensitive polymerase chain reaction, followed by oligonucleotide microarray for genotyping.Results:Human papillomavirus 16 DNA was extracted from portio vaginalis and pelvic nodes of both women. Viral homology between cervical and lymph nodal lesions helped to identify the primary metastasizing tumors in both patients.Conclusions:Human papillomavirus testing on pelvic lymphatic tissue represents a feasible tool to detect the primary site of lymphatic spread in synchronous gynecological malignancies, when uterine cervix is involved.

Journal

International Journal of Gynecological CancerBritish Medical Journal

Published: Oct 1, 2010

Keywords: Synchronous gynecological tumorsHPV testing and genotypingPelvic node metastasesPrimary metastasizing site

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