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Clinical impact of delaying initiation of radiotherapy in patients with breast cancer: stages 0, I and II, a retrospective observational study

Clinical impact of delaying initiation of radiotherapy in patients with breast cancer: stages 0,... AbstractBackgroundThere is no consensus on how long the initiation of radiotherapy (RT) can be delayed after surgery without a negative impact on survival.Materials and methodsWe conducted a retrospective study of 278 patients with stage 0–II breast cancer, all of whom were treated with surgery and RT, with those at stages I–II also receiving chemotherapy. Patients were followed-up for 5 years after diagnosis to assess disease-free and overall survival.The independent variable was the delay in the initiation of RT, assessed by two criteria: time since the last treatment, considered acceptable if ≤6 weeks, and time since surgery, considered acceptable if ≤7 months, these cut-offs being used to categorise patients into two groups according to the length of delay.ResultsNo statistically significant differences were observed in the probability of disease-free survival (p=0·412) or overall survival (p=0·890). The appearance of recurrence was 5–59 months, with an average of 38·50 (14·31).ConclusionsDelaying the initiation of RT for more than 6 weeks after last treatment does not seem to have a negative impact on disease-free or overall survival. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Radiotherapy in Practice Cambridge University Press

Clinical impact of delaying initiation of radiotherapy in patients with breast cancer: stages 0, I and II, a retrospective observational study

Journal of Radiotherapy in Practice , Volume 14 (3): 8 – Jul 24, 2015
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Publisher
Cambridge University Press
Copyright
© Cambridge University Press 2015 
ISSN
1467-1131
eISSN
1460-3969
DOI
10.1017/S1460396915000230
Publisher site
See Article on Publisher Site

Abstract

AbstractBackgroundThere is no consensus on how long the initiation of radiotherapy (RT) can be delayed after surgery without a negative impact on survival.Materials and methodsWe conducted a retrospective study of 278 patients with stage 0–II breast cancer, all of whom were treated with surgery and RT, with those at stages I–II also receiving chemotherapy. Patients were followed-up for 5 years after diagnosis to assess disease-free and overall survival.The independent variable was the delay in the initiation of RT, assessed by two criteria: time since the last treatment, considered acceptable if ≤6 weeks, and time since surgery, considered acceptable if ≤7 months, these cut-offs being used to categorise patients into two groups according to the length of delay.ResultsNo statistically significant differences were observed in the probability of disease-free survival (p=0·412) or overall survival (p=0·890). The appearance of recurrence was 5–59 months, with an average of 38·50 (14·31).ConclusionsDelaying the initiation of RT for more than 6 weeks after last treatment does not seem to have a negative impact on disease-free or overall survival.

Journal

Journal of Radiotherapy in Practice – Cambridge University Press

Published: Jul 24, 2015

Keywords: adjuvant radiotherapy; breast neoplasm; disease-free survival; mortality; recurrences

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