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In Response to “Caution in comparing keloid treatment regimens through linear quadratic model”

In Response to “Caution in comparing keloid treatment regimens through linear quadratic model” sDear Editor,sWe have read with interest the Letter to the Editor titled “Caution in comparing keloid treatment regimens through linear quadratic model” by Ahmad and Rauf Khattak.s1sIn this letter the authors comments on our articles2sand raise pertinent points regarding the selection of α/β value and time/repopulation correction factor while comparing the results of different treatment regimens. We would like to thank the authors for their interest in our publication and we appreciate the opportunity to respond to their letter.sFirst of all, we need to clarify that in our retrospective study the biological effective dose (BED) of each scheme was calculated using a linear quadratic model in order to compare the clinical outcomes in terms of success rate. The linear quadratic-BED was introduced to circumvent the differences in different radiation dose regimens. The radiation doses of different regimens have been normalised to BEDs to be able to compare the success rates on the same scale, that is BED. The selection of α/β value seems to have no influence on the clinical outcomes in our study; rather it worked just as a scaling factor. Nevertheless, it is important to point out that the selection of α/β value has importance in clinical http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Radiotherapy in Practice Cambridge University Press

In Response to “Caution in comparing keloid treatment regimens through linear quadratic model”

Journal of Radiotherapy in Practice , Volume 17 (1): 2 – Jan 8, 2018
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Publisher
Cambridge University Press
Copyright
© Cambridge University Press 2018 
ISSN
1467-1131
eISSN
1460-3969
DOI
10.1017/S146039691700070X
Publisher site
See Article on Publisher Site

Abstract

sDear Editor,sWe have read with interest the Letter to the Editor titled “Caution in comparing keloid treatment regimens through linear quadratic model” by Ahmad and Rauf Khattak.s1sIn this letter the authors comments on our articles2sand raise pertinent points regarding the selection of α/β value and time/repopulation correction factor while comparing the results of different treatment regimens. We would like to thank the authors for their interest in our publication and we appreciate the opportunity to respond to their letter.sFirst of all, we need to clarify that in our retrospective study the biological effective dose (BED) of each scheme was calculated using a linear quadratic model in order to compare the clinical outcomes in terms of success rate. The linear quadratic-BED was introduced to circumvent the differences in different radiation dose regimens. The radiation doses of different regimens have been normalised to BEDs to be able to compare the success rates on the same scale, that is BED. The selection of α/β value seems to have no influence on the clinical outcomes in our study; rather it worked just as a scaling factor. Nevertheless, it is important to point out that the selection of α/β value has importance in clinical

Journal

Journal of Radiotherapy in Practice – Cambridge University Press

Published: Jan 8, 2018

References

  • Caution in comparing keloid treatment regimens through linear quadratic model
  • Postoperative single versus multiple fractions high-dose rate iridium-192 surface mould brachytherapy for keloid treatment: a comparative study
  • Assessment of radiobiological α/β ratio in lung cancer and fibroblast cell lines using viability assays
  • A radiobiological analysis of multicenter data for postoperative keloid radiotherapy
  • Surgical excision and adjuvant brachytherapy vs external beam radiation for the effective treatment of keloids: 10-year institutional retrospective analysis
  • Biologically effective doses of postoperative radiotherapy in the prevention of keloids dose-effect relationship