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Radiosurgery of vestibular schwannomas: summary of experience in 829 cases

Radiosurgery of vestibular schwannomas: summary of experience in 829 cases <jats:p content-type="fine-print"><jats:italic>Object.</jats:italic> Management options for vestibular schwannomas (VSs) have greatly expanded since the introduction of stereotactic radiosurgery. Optimal outcomes reflect long-term tumor control, preservation of cranial nerve function, and retention of quality of life. The authors review their 15-year experience.</jats:p> <jats:p content-type="fine-print"><jats:italic>Methods.</jats:italic> Between 1987 and 2002, some 829 patients with VSs underwent gamma knife surgery (GKS). Dose selection, imaging, and dose planning techniques evolved between 1987 and 1992 but thereafter remained stable for 10 years. The average tumor volume was 2.5 cm<jats:sup>3</jats:sup>. The median margin dose to the tumor was 13 Gy (range 10–20 Gy).</jats:p> <jats:p content-type="fine-print">No patient sustained significant perioperative morbidity. The average duration of hospital stay was less than 1 day. Unchanged hearing preservation was possible in 50 to 77% of patients (up to 90% in those with intracanalicular tumors). Facial neuropathy risks were reduced to less than 1%. Trigeminal symptoms were detected in less than 3% of patients whose tumors reached the level of the trigeminal nerve. Tumor control rates at 10 years were 97% (no additional treatment needed).</jats:p> <jats:p content-type="fine-print"><jats:italic>Conclusions.</jats:italic> Superior imaging, multiple isocenter volumetric conformal dose planning, and optimal precision and dose delivery contributed to the long-term success of GKS, including in those patients in whom initial microsurgery had failed. Gamma knife surgery provides a low risk, minimally invasive treatment option for patients with newly diagnosed or residual VS. Cranial nerve preservation and quality of life maintenance are possible in long-term follow up.</jats:p> http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Neurosurgery CrossRef

Radiosurgery of vestibular schwannomas: summary of experience in 829 cases

Journal of Neurosurgery , Volume 102 (Special_Supplement): 195-199 – Jan 1, 2005

Radiosurgery of vestibular schwannomas: summary of experience in 829 cases


Abstract

<jats:p content-type="fine-print"><jats:italic>Object.</jats:italic> Management options for vestibular schwannomas (VSs) have greatly expanded since the introduction of stereotactic radiosurgery. Optimal outcomes reflect long-term tumor control, preservation of cranial nerve function, and retention of quality of life. The authors review their 15-year experience.</jats:p>
<jats:p content-type="fine-print"><jats:italic>Methods.</jats:italic> Between 1987 and 2002, some 829 patients with VSs underwent gamma knife surgery (GKS). Dose selection, imaging, and dose planning techniques evolved between 1987 and 1992 but thereafter remained stable for 10 years. The average tumor volume was 2.5 cm<jats:sup>3</jats:sup>. The median margin dose to the tumor was 13 Gy (range 10–20 Gy).</jats:p>
<jats:p content-type="fine-print">No patient sustained significant perioperative morbidity. The average duration of hospital stay was less than 1 day. Unchanged hearing preservation was possible in 50 to 77% of patients (up to 90% in those with intracanalicular tumors). Facial neuropathy risks were reduced to less than 1%. Trigeminal symptoms were detected in less than 3% of patients whose tumors reached the level of the trigeminal nerve. Tumor control rates at 10 years were 97% (no additional treatment needed).</jats:p>
<jats:p content-type="fine-print"><jats:italic>Conclusions.</jats:italic> Superior imaging, multiple isocenter volumetric conformal dose planning, and optimal precision and dose delivery contributed to the long-term success of GKS, including in those patients in whom initial microsurgery had failed. Gamma knife surgery provides a low risk, minimally invasive treatment option for patients with newly diagnosed or residual VS. Cranial nerve preservation and quality of life maintenance are possible in long-term follow up.</jats:p>

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Publisher
CrossRef
ISSN
0022-3085
DOI
10.3171/sup.2005.102.s_supplement.0195
Publisher site
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Abstract

<jats:p content-type="fine-print"><jats:italic>Object.</jats:italic> Management options for vestibular schwannomas (VSs) have greatly expanded since the introduction of stereotactic radiosurgery. Optimal outcomes reflect long-term tumor control, preservation of cranial nerve function, and retention of quality of life. The authors review their 15-year experience.</jats:p> <jats:p content-type="fine-print"><jats:italic>Methods.</jats:italic> Between 1987 and 2002, some 829 patients with VSs underwent gamma knife surgery (GKS). Dose selection, imaging, and dose planning techniques evolved between 1987 and 1992 but thereafter remained stable for 10 years. The average tumor volume was 2.5 cm<jats:sup>3</jats:sup>. The median margin dose to the tumor was 13 Gy (range 10–20 Gy).</jats:p> <jats:p content-type="fine-print">No patient sustained significant perioperative morbidity. The average duration of hospital stay was less than 1 day. Unchanged hearing preservation was possible in 50 to 77% of patients (up to 90% in those with intracanalicular tumors). Facial neuropathy risks were reduced to less than 1%. Trigeminal symptoms were detected in less than 3% of patients whose tumors reached the level of the trigeminal nerve. Tumor control rates at 10 years were 97% (no additional treatment needed).</jats:p> <jats:p content-type="fine-print"><jats:italic>Conclusions.</jats:italic> Superior imaging, multiple isocenter volumetric conformal dose planning, and optimal precision and dose delivery contributed to the long-term success of GKS, including in those patients in whom initial microsurgery had failed. Gamma knife surgery provides a low risk, minimally invasive treatment option for patients with newly diagnosed or residual VS. Cranial nerve preservation and quality of life maintenance are possible in long-term follow up.</jats:p>

Journal

Journal of NeurosurgeryCrossRef

Published: Jan 1, 2005

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