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Histopathological Characteristics and Expression of CDV-NP Antigen in the Brain of Serologically Positive Spontaneously Infected Red Foxes (Vulpes Vulpes) In Western Serbia

Histopathological Characteristics and Expression of CDV-NP Antigen in the Brain of Serologically... AbstractCanine distemper virus (CDV) is a worldwide distributed RNA virus that can cause severe disease in carnivore and non-carnivore species. Red foxes are highly susceptible and may act as a reservoir of the virus. As in other wild species, distemper in red foxes can manifest as acute, systemic and chronic nervous form. In the present study, we detected antibodies against CDV among red foxes in Western Serbia, and analyzed histopathologically and immunohistochemically for CDV nuclear protein antigen (CDV-NP) brain samples derived from seropositive animals. Seroprevalence of CDV antibodies was 36.8%. Histopathological changes included gliosis, neuronal degeneration, satellitosis, mononuclear inflammation, demyelination and presence of inclusion bodies. Immunostaining showed a diffuse presence of CDV-NP antigen, mainly in the cytoplasm of astrocytes and neurons. Results of this work contribute to the opinion that red foxes act as a potential reservoir of CDV and underline the importance of routine vaccination of dogs that could come in close contact with these animals. Potential active surveillance program would give a better insight in the degree of CDV infection in wildlife. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Veterinaria de Gruyter

Histopathological Characteristics and Expression of CDV-NP Antigen in the Brain of Serologically Positive Spontaneously Infected Red Foxes (Vulpes Vulpes) In Western Serbia

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Publisher
de Gruyter
Copyright
© 2018 Aničić Milan et al., published by Sciendo
ISSN
1820-7448
eISSN
1820-7448
DOI
10.2478/acve-2018-0035
Publisher site
See Article on Publisher Site

Abstract

AbstractCanine distemper virus (CDV) is a worldwide distributed RNA virus that can cause severe disease in carnivore and non-carnivore species. Red foxes are highly susceptible and may act as a reservoir of the virus. As in other wild species, distemper in red foxes can manifest as acute, systemic and chronic nervous form. In the present study, we detected antibodies against CDV among red foxes in Western Serbia, and analyzed histopathologically and immunohistochemically for CDV nuclear protein antigen (CDV-NP) brain samples derived from seropositive animals. Seroprevalence of CDV antibodies was 36.8%. Histopathological changes included gliosis, neuronal degeneration, satellitosis, mononuclear inflammation, demyelination and presence of inclusion bodies. Immunostaining showed a diffuse presence of CDV-NP antigen, mainly in the cytoplasm of astrocytes and neurons. Results of this work contribute to the opinion that red foxes act as a potential reservoir of CDV and underline the importance of routine vaccination of dogs that could come in close contact with these animals. Potential active surveillance program would give a better insight in the degree of CDV infection in wildlife.

Journal

Acta Veterinaria – de Gruyter

Published: Dec 1, 2018

Keywords: brain; canine distemper virus; histopathology; immunohistochemistry; red fox

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